首页> 美国卫生研究院文献>Journal of Clinical Oncology >Results of the Intergroup Rhabdomyosarcoma Study Group D9602 Protocol Using Vincristine and Dactinomycin With or Without Cyclophosphamide and Radiation Therapy for Newly Diagnosed Patients With Low-Risk Embryonal Rhabdomyosarcoma: A Report From the Soft Tissue Sarcoma Committee of the Childrens Oncology Group
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Results of the Intergroup Rhabdomyosarcoma Study Group D9602 Protocol Using Vincristine and Dactinomycin With or Without Cyclophosphamide and Radiation Therapy for Newly Diagnosed Patients With Low-Risk Embryonal Rhabdomyosarcoma: A Report From the Soft Tissue Sarcoma Committee of the Childrens Oncology Group

机译:组间横纹肌肉瘤研究组D9602方案的结果使用长春新碱和放线菌素联合或不联合环磷酰胺和放射疗法对新诊断的低风险胚胎性横纹肌肉瘤患者:儿童肿瘤学组软组织肉瘤委员会的报告

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摘要

PurposePatients with localized, grossly resected, or gross residual (orbital only) embryonal rhabdomyosarcoma (ERMS) had 5-year failure-free survival (FFS) rates of 83% and overall survival rates of 95% on Intergroup Rhabdomyosarcoma Study Group (IRSG) protocols III/IV. IRSG D9602 protocol (1997 to 2004) objectives were to decrease toxicity in similar patients by reducing radiotherapy (RT) doses and eliminating cyclophosphamide for the lowest-risk patients.
机译:目的根据组间横纹肌肉瘤研究组(IRSG)协议,具有局部,大体切除或大残留(仅眼眶)胚胎性横纹肌肉瘤(ERMS)的患者的5年无衰竭生存率(FFS)为83%,总生存率为95% III / IV。 IRSG D9602协议(1997年至2004年)的目标是通过降低放射治疗(RT)剂量并消除风险最低的患者的环磷酰胺来降低类似患者的毒性。

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