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Evaluation of the Antiviral Response to Zanamivir Administered Intravenously for Treatment of Critically Ill Patients With Pandemic Influenza A (H1N1) Infection

机译：静脉输注扎那米韦抗病毒反应的评估用于治疗重症甲型H1N1流感重症患者

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A retrospective nationwide study on the use of intravenous (IV) zanamivir in patients receiving intensive care who were pretreated with oseltamivir in the Netherlands was performed. In 6 of 13 patients with a sustained reduction of the viral load, the median time to start IV zanamivir was 9 days (range, 4–11 days) compared with 14 days (range, 6–21 days) in 7 patients without viral load reduction (P = .052). Viral load response did not influence mortality. We conclude that IV zanamivir as late add-on therapy has limited effectiveness. The effect of an immediate start with IV zanamivir monotherapy or in combination with other drugs need to be evaluated.

机译：在荷兰进行了一项回顾性全国性研究，该研究对接受奥塞米韦预处理的重症监护患者使用扎那米韦静脉注射治疗。在13例病毒载量持续降低的患者中，开始进行扎那米韦的中位时间为9天（范围4-11天），而7例无病毒载量的患者开始14天（范围6-21天）减少（P = .052）。病毒负荷反应不影响死亡率。我们得出结论，静脉注射扎那米韦作为晚期附加疗法疗效有限。立即评估IV扎那米韦单药治疗或与其他药物联合使用的效果。

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期刊名称 The Journal of Infectious Diseases
作者
P. L. A. Fraaij; E. van der Vries; M. F. C. Beersma; A. Riezebos-Brilman; H. G. M. Niesters; A. A. van der Eijk; M. D. de Jong; D. Reis Miranda; A. M. Horrevorts; B. U. Ridwan; M. J. H. M. Wolfhagen; R. J. Houmes; J. T. van Dissel; R. A. M. Fouchier; A. C. M. Kroes; M. P. Koopmans; A. D. M. E. Osterhaus; C. A. B Boucher;
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年(卷),期 -1(204),5
年度 -1
页码 777–782
总页数 6
原文格式 PDF
正文语种
中图分类免疫学;微生物学;病毒传染病;
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专利

1. Evaluation of the antiviral response to zanamivir administered intravenously for treatment of critically ill patients with pandemic influenza A (H1N1) infection. [J] . Fraaij PL, van der Vries E, Beersma MF, The Journal of Infectious Diseases . 2011,第5期

机译：评估对扎那米韦进行静脉注射以治疗A型大流行性流感（H1N1）重症患者的抗病毒反应。
2. Evaluation of the Antiviral Response to Zanamivir Administered Intravenously for Treatment of Critically Ill Patients With Pandemic Influenza A (H1N1) Infection [J] . P. L. A. Fraaij, E. van der Vries, M. F. C. Beersma, Journal of Infectious Diseases . 2011,第5期

机译：静脉输注扎那米韦抗病毒反应的评估，用于治疗重症甲型H1N1流感重症患者
3. Failure of combination oral oseltamivir and inhaled zanamivir antiviral treatment in ventilator- and ECMO-treated critically ill patients with pandemic influenza A (H1N1)v. [J] . Petersen E, Keld DB, Ellermann Eriksen S, Scandinavian journal of infectious diseases. . 2011,第6a7期

机译：在呼吸机和ECMO治疗的重症甲型流感（H1N1）v重症患者中，口服奥司他韦和吸入扎那米韦抗病毒药物联合治疗失败。
4. Experimental infection of pigs with the 1918 pandemic influenza resembles infection with theclassical H1N1 swine influenza [C] . Hana M. Weingartl, Randy A. Albrecht, Kelly Lager, Congress ofthe International Pig Veterinary Society . 2008

机译：猪的实验性感染与1918百流行的流感类似于感染的感染H1N1猪流感
5. Characterization of vaccine-associated enhanced respiratory disease (VAERD) in swine administered an inactivated delta-cluster influenza vaccine and challenged with pandemic A/H1N1 virus. [D] . Gauger, Phillip C. 2012

机译：接种灭活的δ-集群流感疫苗并受到大流行A / H1N1病毒攻击的猪中与疫苗相关的增强呼吸道疾病（VAERD）的特征。
6. Treatment of Immunocompromised Critically Ill Patients with Influenza A H1N1 Infection with a Combination of Oseltamivir Amantadine and Zanamivir [O] . Wouter J. Meijer, Wiete Kromdijk, Marcel P. H. van den Broek, 2015

机译：结合使用OseltamivirAmantandine和Zanamivir的A型H1N1流感免疫受损严重危重病人的治疗
7. Evaluation of the Antiviral Response to Zanamivir Administered Intravenously for Treatment of Critically Ill Patients With Pandemic Influenza A (H1N1) Infection [O] . Fraaij, P. L. A., van der Vries, E., Beersma, M. F. C., 2011

机译：静脉输注扎那米韦抗病毒反应的评估，用于治疗重症甲型H1N1流感重症患者

Evaluation of the Antiviral Response to Zanamivir Administered Intravenously for Treatment of Critically Ill Patients With Pandemic Influenza A (H1N1) Infection

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