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首页> 美国卫生研究院文献>Journal of Medicinal Food >Flavonoid Detection in Hydroethanolic Extract of Pouteria torta (Sapotaceae) Leaves by HPLC-DAD and the Determination of Its Mutagenic Activity
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Flavonoid Detection in Hydroethanolic Extract of Pouteria torta (Sapotaceae) Leaves by HPLC-DAD and the Determination of Its Mutagenic Activity

机译：HPLC-DAD法测定苦参叶乙醇提取物中的类黄酮含量及其诱变活性

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摘要

It is well known that phytotherapy has grown in popularity in recent years. Because a drug cannot be administered without ensuring its effectiveness and safety, the standardization and regulation of phytotherapeutic drugs are required by the global market and governmental authorities. This article describes a simple and reliable high-performance liquid chromatography–diode array detection analysis method for the simultaneous detection of myricetin-3-O-β-D-galactopyranoside, myricetin-3-O-α-L-arabinopyranoside, and myricetin-3-O-α-L-rhaminopyranoside present in the hydroethanolic extract (ethanol/H2O, 7:3, v/v) of Pouteria torta. The mutagenic activity of the extract was evaluated on Salmonella typhimurium and by an in vivo micronucleus test on the peripheral blood cells of Swiss mice. The linearity, sensitivity, selectivity, repeatability, accuracy, and precision of the assay were evaluated. The analytical curves were linear and exhibited good repeatability (with a deviation of less than 5%) and demonstrated good recovery (within the 83–107% range). The results demonstrate that the hydroethanolic extract exhibited a mutagenic activity in both assays, suggesting caution in the use of this plant in folk medicine.
机译：众所周知，近年来，植物疗法日益普及。由于不能在不确保其有效性和安全性的情况下进行药物管理，因此全球市场和政府机构都需要对植物治疗药物进行标准化和监管。本文介绍了一种简单可靠的高效液相色谱-二极管阵列检测分析方法，用于同时检测杨梅素-3-O-β-D-吡喃半乳糖苷，杨梅素-3-O-α-L-阿拉伯吡喃糖苷和杨梅素- Pouteria torta的氢乙醇提取物（乙醇/ H2O，7：3，v / v）中存在3-O-α-L-氨基氨基吡喃糖苷。通过对鼠伤寒沙门氏菌和瑞士小鼠外周血细胞的体内微核试验评估了提取物的诱变活性。评价了线性，灵敏度，选择性，重复性，准确性和精密度。分析曲线是线性的，显示出良好的重复性（偏差小于5％），并具有良好的回收率（在83-107％范围内）。结果表明，氢乙醇提取物在两种测定中均表现出诱变活性，提示在民间医学中使用这种植物要谨慎。

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