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首页> 美国卫生研究院文献>Journal of Medicinal Food >Ultrafine Angelica gigas Powder Normalizes Ovarian Hormone Levels and Has Antiosteoporosis Properties in Ovariectomized Rats: Particle Size Effect
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Ultrafine Angelica gigas Powder Normalizes Ovarian Hormone Levels and Has Antiosteoporosis Properties in Ovariectomized Rats: Particle Size Effect

机译：当归超细粉能使卵巢切除大鼠的卵巢激素水平正常化并具有抗骨质疏松特性：粒径效应

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The root of Angelica gigas (Korean angelica) is traditionally used to treat women's ailments that are caused by an impairment of menstrual blood flow and cycle irregularities. This study evaluated the effect particle size of Korean angelica powder on its efficacy for treating estrogen-related symptoms of menopause. Initially, Korean angelica roots were pulverized into ultrafine powder, and orally administered to the rats at a concentration of 500 mg/kg body weight for 8 weeks. The effects of Korean angelica powder particle size on extraction yield, contents of bioactive compounds (decursin and decursinol angelate), levels of serum ovarian hormones (estradiol and progesterone), reproductive hormones (luteinizing hormone and follicle-stimulating hormone), and experimental osteoporosis parameters (mineral density, strength, and histological features) were determined. A significant increase (fivefold) in the contents of decursin and decursinol angelate in the extract of the ultrafine Korean angelica powder was observed compared to coarse Korean angelica powder. Rats were divided into sham-operated or ovariectomized (OVX) groups that were fed coarse (CRS) or ultrafine (UF) ground Korean angelica root. The serum levels of estradiol in the OVX_UF group were 19.2% and 54.1% higher than that of OVX_CRS group. Serum bone-alkaline phosphatase/total-alkaline phosphatase index in the OVX_UF group was half that of the OVX_CRS group. In addition, less trabecular bone loss and thick cortical areas were observed in rats administered ultrafine powder. Therefore, ultrafine grinding may enhance the bioactivity of herbal medicines and be especially useful when their extracted forms lose bioactivity during processing, storage, and oral intake.
机译：当归的根（韩国当归）传统上用于治疗因月经不畅和周期不规律而引起的女性疾病。这项研究评估了韩国当归粉的粒度对其治疗更年期雌激素相关症状的功效。最初，将韩国当归根粉碎成超细粉末，并以500μmg/ kg体重的浓度口服给予大鼠8周。当归粉的粒径对提取率，生物活性化合物含量（松果素和癸中醇的含量），血清卵巢激素（雌二醇和孕酮），生殖激素（促黄体激素和促卵泡激素）水平以及实验性骨质疏松参数的影响（矿物质密度，强度和组织学特征）已确定。与韩国粗当归粉相比，观察到超细韩国当归粉提取物中的海藻素和去水醇酚的含量显着增加（五倍）。将大鼠分为假手术组或卵巢切除组（OVX），分别饲喂粗（CRS）或超细（UF）研磨的韩国当归根。 OVX_UF组的血清雌二醇水平比OVX_CRS组高19.2％和54.1％。 OVX_UF组的血清骨碱性磷酸酶/总碱性磷酸酶指数是OVX_CRS组的一半。此外，在使用超细粉的大鼠中，观察到小梁骨损失少，皮质区域厚。因此，超细研磨可以增强草药的生物活性，当它们的提取物在加工，储存和口服过程中失去生物活性时，特别有用。

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