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首页> 美国卫生研究院文献>Journal of Nuclear Medicine >Intraoperative Imaging of Tumors Using Cerenkov Luminescence Endoscopy: A Feasibility Experimental Study
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Intraoperative Imaging of Tumors Using Cerenkov Luminescence Endoscopy: A Feasibility Experimental Study

机译：切伦科夫发光内窥镜对肿瘤进行术中成像的可行性实验研究

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Cerenkov luminescence imaging (CLI) is an emerging new molecular imaging modality that is relatively inexpensive, easy to use, and has high throughput. CLI can image clinically available PET and SPECT probes using optical instrumentation. Cerenkov luminescence endoscopy (CLE) is one of the most intriguing applications that promise potential clinical translation. We developed a prototype customized fiberscopic Cerenkov imaging system to investigate the potential in guiding minimally invasive surgical resection.MethodsAll experiments were performed in a dark chamber. Cerenkov luminescence from 18F-FDG samples containing decaying radioactivity was transmitted through an optical fiber bundle and imaged by an intensified charge-coupled device camera. Phantoms filled with 18F-FDG were used to assess the imaging spatial resolution. Finally, mice bearing subcutaneous C6 glioma cells were injected intravenously with 18F-FDG to determine the feasibility of in vivo imaging. The tumor tissues were exposed, and CLI was performed on the mouse before and after surgical removal of the tumor using the fiber-based imaging system and compared with a commercial optical imaging system.
机译：切伦科夫（Cerenkov）发光成像（CLI）是一种新兴的新型分子成像方式，相对便宜，易于使用且具有高通量。 CLI可以使用光学仪器对临床上可用的PET和SPECT探针成像。切伦科夫发光内窥镜（CLE）是最诱人的应用之一，有望实现潜在的临床翻译。我们开发了原型定制的纤维Cerenkov成像系统，以研究指导微创手术切除的潜力。方法所有实验均在暗室中进行。放射性衰变的 18 F-FDG样品的切伦科夫发光通过光纤束传输，并通过增强的电荷耦合器件照相机成像。用充满 18 F-FDG的幻像评估成像空间分辨率。最后，给带有皮下C6神经胶质瘤细胞的小鼠静脉注射 18 F-FDG，以确定体内成像的可行性。暴露肿瘤组织，并使用基于光纤的成像系统在手术切除肿瘤之前和之后在小鼠上进行CLI，并将其与商用光学成像系统进行比较。

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