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Dietary Reference Intakes for Zinc May Require Adjustment for Phytate Intake Based upon Model Predictions

机译:锌的膳食参考摄入量可能需要根据模型预测调整植酸盐的摄入量

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摘要

The quantity of total dietary zinc (Zn) and phytate are the principal determinants of the quantity of absorbed Zn. Recent estimates of Dietary Reference Intakes (DRI) for Zn by the Institute of Medicine (IOM) were based on data from low-phytate or phytate-free diets. The objective of this project was to estimate the effects of increasing quantities of dietary phytate on these DRI. We used a trivariate model of the quantity of Zn absorbed as a function of dietary Zn and phytate with updated parameters to estimate the phytate effect on the Estimated Average Requirement (EAR) and Recommended Daily Allowance for Zn for both men and women. The EAR predicted from the model at 0 phytate was very close to the EAR of the IOM. The addition of 1000 mg phytate doubled the EAR and adding 2000 mg phytate tripled the EAR. The model also predicted that the EAR for men and women could not be attained with phytate:Zn molar ratios > 11:1 and 15:1, respectively. The phytate effect on upper limits (UL) was predicted by first estimating the quantity of absorbed Zn corresponding to the UL of 40 mg for phytate-free diets, which is 6.4 mg Zn/d. Extrapolation of the model suggested, for example, that with 900 mg/d phytate, 100 mg dietary Zn is required to attain 6.4 mg absorbed Zn/d. Experimental studies with higher Zn intakes are required to test these predictions.
机译:膳食中锌和植酸的总量是决定锌吸收量的主要因素。医学研究所(IOM)对锌的膳食参考摄入量(DRI)的最新估算是基于低肌醇六磷酸或无肌醇六磷酸饮食的数据。该项目的目的是评估膳食植酸盐的添加量对这些DRI的影响。我们使用三元模型来计算吸收的锌量与膳食锌和植酸盐的关系,并使用更新的参数来估算植酸盐对男女的锌估计平均需求量(EAR)和建议的每日锌允许量的影响。根据模型在0植酸时预测的EAR非常接近IOM的EAR。添加1000毫克肌醇六磷酸可以使EAR增加一倍,而添加2000毫克肌醇六磷酸可以使EAR增加三倍。该模型还预测,分别以> 11:1和15:1的植酸盐/锌摩尔比无法获得男性和女性的EAR。肌醇六磷酸对上限(UL)的影响是通过首先估算无锌饮食中对应于40毫克UL的锌吸收量来估算的,即6.4毫克锌/天。该模型的推断表明,例如,对于900 mg / d的肌醇六磷酸,需要100 mg的膳食锌才能达到6.4 mg的吸收锌/ d。需要更多锌摄入量的实验研究来检验这些预测。

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