Marijuana-based Drugs: Innovative Therapeutics or Designer Drugs of Abuse?

机译：以大麻为基础的药物：是创新疗法还是滥用滥用名牌药物？

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Marijuana has been used recreationally and medicinally for centuries. The principle psychoactive component, Δ⁹-tetrahydrocannabinol (Δ⁹-THC), activates CB1 cannabinoid receptors (CB1Rs). CB1R agonists and antagonists could potentially treat a wide variety of diseases; unfortunately, therapeutic doses produce unacceptable psychiatric effects. “K2” or “Spice” (K2/Spice), an emerging drug of abuse, exhibits psychotropic actions via CB1R activation. Because of structural dissimilarity to Δ⁹-THC, these drugs are widely unregulated and touted as “legal” marijuana. This review summarizes current and future therapeutic uses of CB1R ligands and provides a historical perspective of the K2/Spice “phenomenon” so the reader can decide if marijuana-based drugs will truly provide innovative therapeutics or instead perpetuate drug abuse.

机译：大麻已经在娱乐和医学上使用了几个世纪。主要的精神活性成分Δ^{9 -四氢大麻酚（Δ^{9 -THC）激活CB1大麻素受体（CB1Rs）。 CB1R激动剂和拮抗剂可以潜在地治疗多种疾病。不幸的是，治疗剂量会产生无法接受的精神病效果。一种新兴的滥用药物“ K2”或“香料”（K2 / Spice）通过激活CB1R表现出精神行为。由于与Δ^{9 -THC的结构不同，因此这些药物广泛不受管制，并被吹捧为“合法”大麻。这篇综述总结了CB1R配体的当前和未来治疗用途，并提供了K2 / Spice“现象”的历史观点，以便读者可以决定基于大麻的药物是否将真正提供创新的治疗方法或使药物滥用永久化。}}}

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期刊名称 Molecular Interventions
作者
Kathryn A. Seely; Paul L. Prather; Laura P. James; Jeffery H. Moran;
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年(卷),期 -1(11),1
年度 -1
页码 36–51
总页数 16
原文格式 PDF
正文语种
中图分类分子生物学;
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1. Marijuana-based drugs: innovative therapeutics or designer drugs of abuse? [J] . Seely KA, Prather PL, James LP, Molecular interventions . 2011,第1期

机译：大麻药物：滥用创新药物或名牌药物？
2. Analysis of new designer drugs and common drugs of abuse in urine by a combined targeted and untargeted LC-HR-QTOFMS approach [J] . Michael Paul, Josef Ippisch, Christian Herrmann, Analytical and bioanalytical chemistry . 2014,第18期

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3. Cross-reactivities of 39 new amphetamine designer drugs on three abuse drugs urinary screening tests [J] . Maria Nieddu, Lucia Burrai, Claudia Trignano Gianpiero Boatto Forensic toxicology . 2014,第1期

机译：三种滥用药物尿液筛查测试中39种新的苯丙胺新设计药物的交叉反应性
4. Keynote: THERAPEUTIC DRUG MONITORING AND DRUG DISCOVERY: IS IT ALL KNOWN OR ARE WE INNOVATIVE AND GAME CHANGING? [C] . Ron M. A. Heeren, Filip Cuyckens, Rob J. Vreeken International Mass Spectrometry Conference . 2018

机译：主题演讲：治疗药物监测和药物发现：是否全部已知或我们的创新和游戏变化？
5. Family members and significant others of drug abusers: Characteristics of the relationship with the drug abuser and predictors of outcome in unilateral treatment. [D] . Garvey, Kerry A. 1999

机译：家庭成员和其他主要的吸毒者：与吸毒者的关系特征和单方面治疗结果的预测指标。
6. Evaluation of drug information resources for interactions between therapeutic drugs and drugs of abuse [O] . Robert D. Beckett, Jennifer R. Martin, Curtis D. Stump, 2020

机译：评估药物信息资源用于治疗药物与滥用药物的相互作用
7. Intérêt du Triage$^circledR$ TOX Drug Screen pour le dépistage urinaire de drogues illicites et de médicaments Usefulness of Triage$^{circledR}$ TOX Drug Screen for urinary screening of drugs of abuse and therapeutic drugs [O] . Mura Patrick, Papet Yves, Brunet Bertrand 2008

机译：分流的利息$ ^ circleR $尿液筛查违禁药物和药物的TOX药物筛查的用途Triage $ ^ {circledR} $ TOX尿液筛查滥用药物和治疗性药物的TOX药物筛查
8. Community Demonstration Grant Projects for Alcohol and Drug Abuse Treatment of Homeless Individuals. Volume 3. Innovative Strategies for Treating Alcohol and Drug Abuse Problems among Homeless Men and Women [R] . Murray, M. M. 1992

机译：针对无家可归者的酒精和药物滥用治疗的社区示范资助项目。第3卷。无家可归的男性和女性中治疗酒精和药物滥用问题的创新策略

Marijuana-based Drugs: Innovative Therapeutics or Designer Drugs of Abuse?

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