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首页> 美国卫生研究院文献>Medical Physics >Flow characteristics in a canine aneurysm model: A comparison of 4D accelerated phase-contrast MR measurements and computational fluid dynamics simulations
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Flow characteristics in a canine aneurysm model: A comparison of 4D accelerated phase-contrast MR measurements and computational fluid dynamics simulations

机译：犬动脉瘤模型中的流动特性：4D加速相衬MR测量与计算流体动力学模拟的比较

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>Purpose: Our purpose was to compare quantitatively velocity fields in and around experimental canine aneurysms as measured using an accelerated 4D PC-MR angiography (MRA) method and calculated based on animal-specific CFD simulations.>Methods: Two animals with a surgically created bifurcation aneurysm were imaged using an accelerated 4D PC-MRA method. Meshes were created based on the geometries obtained from the PC-MRA and simulations using “subject-specific” pulsatile velocity waveforms and geometries were then solved using a commercial CFD solver. Qualitative visual assessments and quantitative comparisons of the time-resolved velocity fields obtained from the PC-MRA measurements and the CFD simulations were performed using a defined similarity metric combining both angular and magnitude differences of vector fields.>Results: PC-MRA and image-based CFD not only yielded visually consistent representations of 3D streamlines in and around both aneurysms, but also showed good agreement with regard to the spatial velocity distributions. The estimated similarity between time-resolved velocity fields from both techniques was reasonably high (mean value >0.60; one being the highest and zero being the lowest). Relative differences in inflow and outflow zones among selected planes were also reasonable (on the order of 10%–20%). The correlation between CFD-calculated and PC-MRA-measured time-averaged wall shear stresses was low (0.22 and 0.31, p < 0.001).>Conclusions: In two experimental canine aneurysms, PC-MRA and image-based CFD showed favorable agreement in intra-aneurismal velocity fields. Combining these two complementary techniques likely will further improve the ability to characterize and interpret the complex flow that occurs in human intracranial aneurysms.
机译：>目的：我们的目的是定量比较实验性犬动脉瘤内部和周围的速度场，该速度场是使用加速4D PC-MR血管造影（MRA）方法测量并根据动物特定的CFD模拟计算得出的。>方法：使用加速的4D PC-MRA方法对两只具有外科手术产生的分叉动脉瘤的动物进行成像。根据从PC-MRA获得的几何形状创建网格，并使用“特定于对象的”脉动速度波形进行模拟，然后使用商用CFD求解器求解几何形状。使用定义的相似度度量结合矢量场的角度和幅度差，对从PC-MRA测量和CFD模拟获得的时间分辨速度场进行了定性视觉评估和定量比较。>结果： PC-MRA和基于图像的CFD不仅在两个动脉瘤内和周围产生了视觉上一致的3D流线表示，而且在空间速度分布方面也显示出良好的一致性。两种技术在时间分辨速度场之间的估计相似度都相当高（平均值> 0.60；一个最高，而零则最低）。选定平面之间流入和流出区域的相对差异也是合理的（大约10％–20％）。 CFD计算的和PC-MRA测量的时间平均壁切应力之间的相关性较低（0.22和0.31，p <0.001）。>结论：在两个实验犬动脉瘤中，PC-MRA和图像基于CFD的CFD在动脉内速度场中显示出良好的一致性。结合这两种互补技术可能会进一步提高表征和解释人类颅内动脉瘤中发生的复杂血流的能力。

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