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A Promising Therapeutic Approach for Treatment of Posterior Uveitis: Recombinant T Cell Receptor Ligand Protects Lewis Rats from Acute and Recurrent Experimental Autoimmune Uveitis

机译：一种治疗后葡萄膜炎的有前途的治疗方法：重组T细胞受体配体保护Lewis大鼠免受急性和复发性实验性自身免疫性葡萄膜炎的侵害

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IntroductionChronic autoimmune uveitis is a major cause of vision loss from intraocular inflammation in humans. In this study we report that a recombinant TCR ligand (RTL220) composed of the α1 and β1 domains of MHC class II molecules linked to the uveitogenic interphotoreceptor retinoid-binding protein (IRBP) 1177–1191 peptide is effective in the suppression of acute and recurrent experimental autoimmune uveitis (EAU). Material and Methods: EAU was induced with IRBP1177–1191 peptide or by adoptive transfer of specific T cells in Lewis rats. The rats received 5 doses of RTL220 subcutaneously every other day starting at the onset of clinic signs of EAU.

机译：简介慢性自身免疫性葡萄膜炎是人类眼内炎症导致视力丧失的主要原因。在这项研究中，我们报告说，重组的TCR配体（RTL220）由II类MHC分子的α1和β1结构域连接，其与成血管新生光感受器之间的类视黄醇结合蛋白（IRBP）1177–1191肽有效地抑制了急性和复发性实验性自身免疫性葡萄膜炎（EAU）。材料与方法：用IRBP1177-1119肽或过继转移Lewis大鼠的特定T细胞诱导EAU。从EAU出现临床体征开始，大鼠每隔一天皮下接受5剂RTL220。

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期刊名称 Ophthalmic Research
作者
Grazyna Adamus; Landon J. Karren; Jeff Mooney; Gregory G. Burrows;
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年(卷),期 -1(44),1
年度 -1
页码 24–33
总页数 10
原文格式 PDF
正文语种
中图分类眼科学;
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1. A promising therapeutic approach for treatment of posterior uveitis: recombinant T cell receptor ligand protects Lewis rats from acute and recurrent experimental autoimmune uveitis. [J] . Adamus G, Karren LJ, Mooney J, Ophthalmic Research: Journal for Research in Experimental and Clinical Ophthalmology . 2010,第1期

机译：一种治疗后葡萄膜炎的有前途的治疗方法：重组T细胞受体配体可保护Lewis大鼠免受急性和复发性实验性自身免疫性葡萄膜炎的侵害。
2. Epitope recognition and T cell receptors in recurrent autoimmune anterior uveitis in Lewis rats immunized with myelin basic protein. [J] . Adamus G, Manczak M, Sugden B, Journal of Neuroimmunology: Official Bulletin of the Research Committee on Neuroimmunology of the World Federation of Neurology . 2000,第1a2期

机译：髓鞘碱性蛋白免疫的Lewis大鼠复发性自身免疫性前葡萄膜炎的表位识别和T细胞受体。
3. Comparison of Inflammatory Aqueous Cell Populations from Experimental Autoimmune Uveitis (EAU) and Primed Mycobacterial Uveitis (PMU) in Lewis Rats [J] . Pepple Kathryn L., Van Gelder Russell N. Investigative ophthalmology & visual science . 2017,第8期

机译：路易斯大鼠实验性自身免疫葡萄膜炎（EAU）和灌注分枝杆菌葡萄膜炎（PMU）的炎性含水细胞群的比较
4. DEFORMATION-INDUCED LIFT ON RECEPTOR-LIGAND MEDIATED CELL ADHESION TO SUBSTRATES EXPLORED BY A 3-D COMPUTATIONAL FLUID DYNAMICS APPROACH [C] . Xiaoyi Li, Kausik Sarkar American Society of Mechanical Engineers(ASME) Joint U.S.-European Fluids Engineering Division Summer Conference 2006(FEDSM2006) vol.2; 20060717-20; Miami,FL(US) . 2006

机译：受体-配体介导的细胞粘附对3维计算流体动力学方法探讨的基团的形变诱导提升
5. Induction of hypersignaling as a therapeutic approach for treatment of BCR-ABL1 positive Acute Lymphoblastic Leukemia (ALL) cells. [D] . Shojaee, Seyedmehdi. 2013

机译：诱导高信号作为一种治疗BCR-ABL1阳性急性淋巴细胞白血病（ALL）细胞的治疗方法。
6. A Promising Therapeutic Approach for Multiple Sclerosis: Recombinant T-Cell Receptor Ligands Modulate Experimental Autoimmune Encephalomyelitis by Reducing Interleukin-17 Production and Inhibiting Migration of Encephalitogenic Cells into the CNS [O] . Sushmita Sinha, Sandhya Subramanian, Thomas M. Proctor, 2007

机译：多发性硬化的一种有前途的治疗方法：重组T细胞受体配体通过减少白介素17的产生并抑制致脑细胞迁移到中枢神经系统来调节实验性自身免疫性脑脊髓炎。
7. A Promising Therapeutic Approach for Treatment of Posterior Uveitis: Recombinant T Cell Receptor Ligand Protects Lewis Rats from Acute and Recurrent Experimental Autoimmune Uveitis [O] . Adamus, Grazyna, Karren, Landon J., Mooney, Jeff, 2010

机译：一种治疗后葡萄膜炎的有前途的治疗方法：重组T细胞受体配体可以保护Lewis大鼠免受急性和复发性实验性自身免疫性葡萄膜炎的侵害

A Promising Therapeutic Approach for Treatment of Posterior Uveitis: Recombinant T Cell Receptor Ligand Protects Lewis Rats from Acute and Recurrent Experimental Autoimmune Uveitis

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