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首页> 美国卫生研究院文献>Medical Physics >The feasibility of a scanner-independent technique to estimate organ dose from MDCT scans: Using CTDIvol to account for differences between scanners
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The feasibility of a scanner-independent technique to estimate organ dose from MDCT scans: Using CTDIvol to account for differences between scanners

机译：独立于扫描仪的技术从MDCT扫描估算器官剂量的可行性：使用CTDIvol来解释扫描仪之间的差异

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>Purpose: Monte Carlo radiation transport techniques have made it possible to accurately estimate the radiation dose to radiosensitive organs in patient models from scans performed with modern multidetector row computed tomography (MDCT) scanners. However, there is considerable variation in organ doses across scanners, even when similar acquisition conditions are used. The purpose of this study was to investigate the feasibility of a technique to estimate organ doses that would be scanner independent. This was accomplished by assessing the ability of CTDIvol measurements to account for differences in MDCT scanners that lead to organ dose differences.>Methods: Monte Carlo simulations of 64-slice MDCT scanners from each of the four major manufacturers were performed. An adult female patient model from the GSF family of voxelized phantoms was used in which all ICRP Publication 103 radiosensitive organs were identified. A 120 kVp, full-body helical scan with a pitch of 1 was simulated for each scanner using similar scan protocols across scanners. From each simulated scan, the radiation dose to each organ was obtained on a per mA s basis (mGy∕mA s). In addition, CTDIvol values were obtained from each scanner for the selected scan parameters. Then, to demonstrate the feasibility of generating organ dose estimates from scanner-independent coefficients, the simulated organ dose values resulting from each scanner were normalized by the CTDIvol value for those acquisition conditions.>Results: CTDIvol values across scanners showed considerable variation as the coefficient of variation (CoV) across scanners was 34.1%. The simulated patient scans also demonstrated considerable differences in organ dose values, which varied by up to a factor of approximately 2 between some of the scanners. The CoV across scanners for the simulated organ doses ranged from 26.7% (for the adrenals) to 37.7% (for the thyroid), with a mean CoV of 31.5% across all organs. However, when organ doses are normalized by CTDIvol values, the differences across scanners become very small. For the CTDIvol, normalized dose values the CoVs across scanners for different organs ranged from a minimum of 2.4% (for skin tissue) to a maximum of 8.5% (for the adrenals) with a mean of 5.2%.>Conclusions: This work has revealed that there is considerable variation among modern MDCT scanners in both CTDIvol and organ dose values. Because these variations are similar, CTDIvol can be used as a normalization factor with excellent results. This demonstrates the feasibility of establishing scanner-independent organ dose estimates by using CTDIvol to account for the differences between scanners.
机译：>目的：蒙特卡洛辐射传输技术使得通过现代多探测器行计算机断层扫描（MDCT）扫描仪进行的扫描，可以准确地估算出患者模型中放射敏感性器官的辐射剂量。但是，即使使用类似的采集条件，整个扫描仪的器官剂量也有相当大的差异。这项研究的目的是调查一种估计独立于扫描仪的器官剂量的技术的可行性。这是通过评估CTDIvol测量值来解决导致器官剂量差异的MDCT扫描仪差异的能力来实现的。>方法：四家主要制造商分别对64层MDCT扫描仪进行了蒙特卡洛模拟执行。使用了来自GSF体素化体模家族的成年女性患者模型，其中鉴定了所有ICRP出版物103的放射敏感性器官。使用跨扫描仪的类似扫描协议，为每个扫描仪模拟了螺距为1的120 kVp全身螺旋扫描。从每次模拟扫描中，以每毫安秒（mGy ∕ mA s）为基础，得出了每个器官的辐射剂量。此外，还从每个扫描仪获取了所选扫描参数的CTDIvol值。然后，为了证明从与扫描仪无关的系数生成器官剂量估计值的可行性，将针对每个采集条件的CTDIvol值对每个扫描仪产生的模拟器官剂量值进行归一化。>结果：跨扫描仪的CTDIvol值由于各扫描仪的变异系数（CoV）为34.1％，因此显示出相当大的变异。模拟的患者扫描还显示出器官剂量值的显着差异，其中某些扫描仪之间的器官剂量值相差最多约2倍。扫描仪对模拟器官剂量的CoV在26.7％（对肾上腺）至37.7％（对甲状腺）之间，所有器官的平均CoV为31.5％。但是，当通过CTDIvol值对器官剂量进行标准化时，扫描仪之间的差异将变得很小。对于CTDIvol，归一化剂量值在整个扫描仪中对不同器官的CoV值范围从最小2.4％（对于皮肤组织）到最大8.5％（对于肾上腺），平均为5.2％。>结论：< / strong>这项工作表明，现代MDCT扫描仪在CTDIvol和器官剂量值方面都存在很大差异。由于这些变化相似，因此CTDIvol可以用作归一化因子，并具有出色的结果。这证明了通过使用CTDIvol来解释扫描仪之间的差异，建立与扫描仪无关的器官剂量估计的可行性。

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