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首页> 美国卫生研究院文献>Medical Physics >Simultaneous navigation of multiple Pareto surfaces with an application to multicriteria IMRT planning with multiple beam angle configurations
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Simultaneous navigation of multiple Pareto surfaces with an application to multicriteria IMRT planning with multiple beam angle configurations

机译：同时导航多个帕累托曲面并应用于具有多个光束角度配置的多标准IMRT规划

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>Purpose: To introduce a method to simultaneously explore a collection of Pareto surfaces. The method will allow radiotherapy treatment planners to interactively explore treatment plans for different beam angle configurations as well as different treatment modalities.>Methods: The authors assume a convex optimization setting and represent the Pareto surface for each modality or given beam set by a set of discrete points on the surface. Weighted averages of these discrete points produce a continuous representation of each Pareto surface. The authors calculate a set of Pareto surfaces and use linear programming to navigate across the individual surfaces, allowing switches between surfaces. The switches are organized such that the plan profits in the requested way, while trying to keep the change in dose as small as possible.>Results: The system is demonstrated on a phantom pancreas IMRT case using 100 different five beam configurations and a multicriteria formulation with six objectives. The system has intuitive behavior and is easy to control. Also, because the underlying linear programs are small, the system is fast enough to offer real-time exploration for the Pareto surfaces of the given beam configurations.>Conclusions: The system presented offers a sound starting point for building clinical systems for multicriteria exploration of different modalities and offers a controllable way to explore hundreds of beam angle configurations in IMRT planning, allowing the users to focus their attention on the dose distribution and treatment planning objectives instead of spending excessive time on the technicalities of delivery.
机译：>目的：介绍一种同时探索帕累托曲面集合的方法。该方法将使放射疗法治疗计划制定者可以交互式地探索针对不同束角配置以及不同治疗方式的治疗计划。>方法：作者假设凸优化设置并代表每种方式或给定的帕累托表面光束由表面上的一组离散点设置。这些离散点的加权平均值产生每个帕累托曲面的连续表示。作者计算了一组帕累托曲面，并使用线性编程在各个曲面之间导航，从而允许在曲面之间切换。开关的组织方式使计划以所请求的方式获利，同时试图使剂量的变化保持尽可能小。>结果：该系统在幻影胰腺IMRT案例中演示，使用了100种不同的五种梁配置和具有六个目标的多准则制定。该系统具有直观的行为，易于控制。另外，由于基本的线性程序很小，因此该系统足够快，可以为给定光束配置的帕累托曲面提供实时探索。>结论：所提供的系统为构建提供了良好的起点用于多种方式的多标准探索的临床系统，并提供了一种可控制的方式来探索IMRT计划中的数百个射束角度配置，使用户可以将注意力集中在剂量分布和治疗计划目标上，而不必花费大量时间在运送技术上。

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