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Adsorption of metallic radionuclides on plastic phantom walls

机译：金属放射性核素在塑料幻影壁上的吸附

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摘要

Metal radionuclide solutions at neutral pH adhere to plastic containers. Adsorption of radionuclides on the walls of phantoms leads to a nonuniform activity distribution, which could adversely affect imaging studies, as well as phantom-based validations of absorbed dose calculations used in radioimmunotherapy, requiring accurate knowledge of the underlying activity distribution. In the work reported here, the authors determined the degree of metal chelation required to minimize metallic radionuclide oxide formation and adsorption on phantom walls in order to yield more reliable experimental data for validating image-based dosimetry. Using hollow spherical plastic phantoms, the authors evaluated three different radionuclides, I-131, In-111, and Y-90, in solutions containing three different concentrations of the chelator, ethylenediaminetetraacetate (EDTA). Adsorption to plastic walls was determined using μSPECT imaging and∕or by counting aliquots of solutions. Reconstructed images and measurements of I-131 activity showed that it was uniformly distributed within all spheres; however, images of In-111 in 0.25-μM EDTA indicated that the activity concentration near the wall was much higher than that in the middle of the sphere. The decrease in activity concentration near the center of the spheres was ∼47%. Y-90 in 0.25-μM EDTA behaved similarly; the activity concentration of Y-90 decreased by 46%. For an In-111 or Y-90 radioactivity concentration of 0.74 MBq∕mL, a 2.5-μM EDTA solution was required to achieve a uniform distribution, suggesting that, under our experimental conditions, ∼700 EDTA molecules were required for each radiometal atom to prevent precipitation and adsorption on poly(methylmethacrylate). For certain radiometals, e.g., In-111 or Y-90, adequate chelation is essential to achieve uniform activity concentration values and homogeneous distribution within the phantom compartments.
机译：pH值处于中性的金属放射性核素溶液粘附在塑料容器上。放射性核素在体模壁上的吸附会导致活性分布不均匀，这可能会对成像研究产生不利影响，以及放射免疫疗法中使用的基于体模的吸收剂量计算验证，需要准确了解潜在的活性分布。在这里报道的工作中，作者确定了使金属放射性核素氧化物的形成和在幻影壁上的吸附最小化所需的金属螯合度，以产生更可靠的实验数据来验证基于图像的剂量法。使用空心球形塑料体模，作者在含有三种不同浓度的螯合剂乙二胺四乙酸盐（EDTA）的溶液中评估了三种不同的放射性核素I-131，In-111和Y-90。使用μSPECT成像和/或通过计算溶液的等分试样确定对塑料壁的吸附。重建的图像和I-131活性的测量结果表明，它在所有领域内均一分布；然而，In-111在0.25-μMEDTA中的图像表明，壁附近的活性浓度远高于球体中部。球中心附近的活动浓度降低了约47％。 0.25-μMEDTA中的Y-90表现相似。 Y-90的活性浓度降低了46％。对于0.74 MBq ∕ mL的In-111或Y-90放射性浓度，需要2.5μMEDTA溶液以实现均匀分布，这表明，在我们的实验条件下，每个放射性金属原子需要约700个EDTA分子。防止沉淀和吸附在聚甲基丙烯酸甲酯上。对于某些放射性金属，例如In-111或Y-90，足够的螯合对于实现均匀的活度浓度值和幻像室内的均匀分布至关重要。

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