• 主题
高级搜索  >
历史搜索 清空历史
首页> 美国卫生研究院文献>Therapeutic Hypothermia and Temperature Management >Setting Up an Efficient Therapeutic Hypothermia Team in Conscious ST Elevation Myocardial Infarction Patients: A UK Heart Attack Center Experience
【2h】

Setting Up an Efficient Therapeutic Hypothermia Team in Conscious ST Elevation Myocardial Infarction Patients: A UK Heart Attack Center Experience

机译：在意识增强的ST段抬高型心肌梗死患者中建立高效的治疗性低温治疗团队：英国心脏病发作中心的经验

代理获取
本网站仅为用户提供外文OA文献查询和代理获取服务，本网站没有原文。下单后我们将采用程序或人工为您竭诚获取高质量的原文，但由于OA文献来源多样且变更频繁，仍可能出现获取不到、文献不完整或与标题不符等情况，如果获取不到我们将提供退款服务。请知悉。
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Patients presenting with ST elevation myocardial infarction (STEMI) are routinely treated with percutaneous coronary intervention to restore blood flow in the occluded artery to reduce infarct size (IS). However, there is evidence to suggest that the restoration of blood flow can cause further damage to the myocardium through reperfusion injury (RI). Recent research in this area has focused on minimizing damage to the myocardium caused by RI. Therapeutic hypothermia (TH) has been shown to be beneficial in animal models of coronary artery occlusion in reducing IS caused by RI if instituted early in an ischemic myocardium. Data in humans are less convincing to date, although exploratory analyses suggest that there is significant clinical benefit in reducing IS if TH can be administered at the earliest recognition of ischemia in anterior myocardial infarction. The Essex Cardiothoracic Centre is the first UK center to have participated in administering TH in conscious patients presenting with STEMI as part of the COOL-AMI case series study. In this article, we outline our experience of efficiently integrating conscious TH into our primary percutaneous intervention program to achieve 18 minutes of cooling duration before reperfusion, with no significant increase in door-to-balloon times, in the setting of the clinical trial.
机译：表现为ST抬高型心肌梗塞（STEMI）的患者应常规行经皮冠状动脉介入治疗，以恢复闭塞动脉的血流，以减少梗塞面积（IS）。但是，有证据表明血流的恢复可通过再灌注损伤（RI）进一步损害心肌。该领域的最新研究集中在最小化由RI引起的心肌损伤上。如果在缺血性心肌中较早建立，治疗性低温（TH）在降低冠状动脉引起的IS的冠状动脉闭塞动物模型中已被证明是有益的。迄今为止，人类的数据尚不那么令人信服，尽管探索性分析表明，如果可以在心肌梗塞的早期识别中尽早使用TH，在减少IS方面具有显着的临床益处。作为COOL-AMI病例系列研究的一部分，埃塞克斯心胸中心是英国第一个参与对患有STEMI的意识清醒患者进行TH治疗的中心。在本文中，我们概述了在临床试验中将有意识的TH有效地整合到主要的经皮介入治疗方案中以在再灌注前达到18分钟的冷却时间，而上门气球时间没有明显增加的经验。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
代理获取

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号