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首页> 美国卫生研究院文献>SpringerPlus >Heavy metal exposure in combination with physical activity and aging is related with oxidative stress in Japanese women from a rural agricultural community
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Heavy metal exposure in combination with physical activity and aging is related with oxidative stress in Japanese women from a rural agricultural community

机译：重金属的暴露加上体育锻炼和衰老与来自农村农业社区的日本女性的氧化应激有关

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This study aimed to evaluate the relationships between oxidative stress and heavy metal exposure (lead [Pb] and cadmium [Cd]), as well as co-factors such as physical activity and age, in Japanese women. This study was conducted with female subjects from a rural agricultural community in Japan. Subjects were asked to complete lifestyle-related questionnaires and undergo a group health examination. Physical activity, alcohol consumption, body mass index, and other demographic information were collected. Blood and urine samples were collected to measure urinary 8-hydroxydeoxyguanosine (8-OHdG) levels and blood and urinary Cd and Pb concentrations. Urine samples were analyzed using high performance liquid chromatography and flameless atomic absorption spectrometry; blood samples were analyzed using inductively coupled plasma-mass spectrometry. Age, physical activity, and blood and urinary Cd and Pb concentrations were included in structural equation modeling analysis. Two latent factors for heavy metal exposure and physical activity were produced to predict the total influence of the variables. The final model was good: CMIN/DF = 0.775, CFI = 1.000, GFI = 0.975, AGFI = 0.954, RMSEA = 0.000. 8-OHdG levels were positively associated with heavy metal exposure, physical activity, and age (standard β of path analysis: 0.33, 0.38, and 0.20, respectively). Therefore, oxidative stress is associated with both, environmental and lifestyle factors, in combination with aging.
机译：这项研究旨在评估日本女性中氧化应激与重金属暴露（铅[Pb]和镉[Cd]）之间的关系，以及诸如体育锻炼和年龄等辅助因素。这项研究是针对日本农村农业社区的女性受试者进行的。要求受试者填写与生活方式有关的问卷并进行团体健康检查。收集体育锻炼，酒精消耗，体重指数和其他人口统计信息。收集血液和尿液样本以测量尿中的8-羟基脱氧鸟苷（8-OHdG）水平以及血液和尿中Cd和Pb的浓度。用高效液相色谱和无焰原子吸收光谱法分析尿液样品；使用感应耦合等离子体质谱法分析血样。年龄，体力活动以及血液和尿液中Cd和Pb的浓度都包括在结构方程模型分析中。产生了两个潜在的重金属暴露和体育锻炼潜能因素，以预测变量的总影响。最终模型很好：CMIN / DF = 0.775，CFI = 1.000，GFI = 0.975，AGFI = 0.954，RMSEA = 0.000。 8-OHdG水平与重金属暴露，身体活动和年龄呈正相关（路径分析的标准β分别为0.33、0.38和0.20）。因此，氧化应激与环境因素和生活方式因素以及衰老结合在一起。

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