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首页> 美国卫生研究院文献>Vector Borne and Zoonotic Diseases >Seroepidemiology of Selected Arboviruses in Febrile Patients Visiting Selected Health Facilities in the Lake/River Basin Areas of Lake Baringo Lake Naivasha and Tana River Kenya
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Seroepidemiology of Selected Arboviruses in Febrile Patients Visiting Selected Health Facilities in the Lake/River Basin Areas of Lake Baringo Lake Naivasha and Tana River Kenya

机译：在肯尼亚巴林戈湖奈瓦夏湖和塔纳河湖/河流盆地地区某些医疗机构就诊的高热患者中选择的虫媒病毒的血清流行病学

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>Introduction: Arboviruses cause emerging and re-emerging infections affecting humans and animals. They are spread primarily by blood-sucking insects such as mosquitoes, ticks, midges, and sandflies. Changes in climate, ecology, demographic, land-use patterns, and increasing global travel have been linked to an upsurge in arboviral disease. Outbreaks occur periodically followed by persistent low-level circulation.>Aim: This study was undertaken to determine the seroepidemiology of selected arboviruses among febrile patients in selected lake/river basins of Kenya.>Methods: Using a hospital-based cross-sectional descriptive survey, febrile patients were recruited and their serum samples tested for exposure to immunoglobulin M (IgM) and IgG antibodies against Crimean–Congo hemorrhagic fever virus (CCHFV), Rift Valley fever virus (RVFV), West Nile virus (WNV), and chikungunya virus (CHIKV). Samples positive for CHIKV and WNV were further confirmed by the plaque reduction neutralization test (PRNT).>Results: Of the 379 samples examined, 176 were IgG positive for at least one of these arboviruses (46.4%, 95% confidence interval [CI] 41.4–51.5%). Virus-specific prevalence for CCHF, RVF, WN, and CHIK was 25.6%, 19.5%, 12.4%, and 2.6%, respectively. These prevalences varied significantly with geographical site (p<0.001), with Tana recording the highest overall arboviral seropositivity. PRNT results for Alphaviruses confirmed that the actual viruses circulating in Baringo were Semliki Forest virus (SFV) and CHIKV, o'nyong nyong virus (ONNV) in Naivasha, and SFV and Sindbis virus (SINDV) in Tana delta. Among the flaviviruses tested, WNV was circulating in all the three sites.>Conclusion: There is a high burden of febrile illness in humans due to CCHFV, RVFV, WNV, and CHIKV infection in the river/lake basin regions of Kenya.
机译：>简介：虫媒病毒会引起新出现和重新出现的感染，从而影响人类和动物。它们主要通过吸血昆虫传播，例如蚊子，壁虱，mid和沙蝇。气候，生态，人口，土地利用方式的变化以及全球旅行的增加都与虫媒病毒疾病的激增有关。 >目的：该研究旨在确定肯尼亚部分湖泊/河流盆地高热患者中某些虫媒病毒的血清流行病学。>方法：使用基于医院的横断面描述性调查，招募了高热患者，并测试了他们的血清样本是否暴露于针对克里米亚-刚果出血热病毒（CCHFV），裂谷热病毒（RVFV）的免疫球蛋白M（IgM）和IgG抗体），西尼罗河病毒（WNV）和基孔肯雅病毒（CHIKV）。斑块减少中和试验（PRNT）进一步证实了CHIKV和WNV阳性。>结果：在所检查的379个样品中，至少有一种虫媒病毒176种IgG呈阳性（46.4％，95）置信区间百分比[CI] 41.4–51.5％）。 CCHF，RVF，WN和CHIK的病毒特异性患病率分别为25.6％，19.5％，12.4％和2.6％。这些患病率随地理位置的不同而有显着差异（p <0.001），塔娜（Tana）记录的最高总体病毒学血清阳性。 PRNT对Alphaviruses病毒的结果证实，在Baringo中传播的实际病毒是Semliki Forest病毒（SFV）和CHIKV，Naivasha的o'nyong nyong病毒（ONNV），以及Tana delta的SFV和Sindbis病毒（SINDV）。在测试的黄病毒中，WNV在这三个部位中均在传播。>结论：由于河/湖流域CCHFV，RVFV，WNV和CHIKV感染，人类出现高热病负担肯尼亚地区。

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