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首页> 美国卫生研究院文献>AAPS PharmSciTech >Formulation of Eco-friendly Medicated Chewing Gum to Prevent Motion Sickness
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Formulation of Eco-friendly Medicated Chewing Gum to Prevent Motion Sickness

机译：配制环保药性口香糖防止晕车

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摘要

An attempt was made to formulate medicated chewing gum to prevent motion sickness using natural gum base for faster onset of action and easy administration, anywhere and anytime, without access to water. To avoid the discard issue of gum cud, natural gum base of Triticum aestivum (wheat grain) was explored because of its biodegradable and biocompatible nature and easy availability. Prolamin, extracted from wheat, showed good chewing capacity, elasticity, high water retention capacity, antifungal activity, and compatibility with the drug. Formulations were prepared based on a two-factor and three-level factorial design. Amount of calcium carbonate (texturizer) and gum base were selected as independent variables. Elasticity and drug release were considered as the dependent variables. All batches were evaluated for the content uniformity, elasticity study, texture study, in vitro drug release study, and chewiness study. Results revealed that medicated chewing gum containing 80 mg of calcium carbonate and 500 mg of gum base showed good elasticity and more than 90% drug release within 16 min. Thus, this study suggested that both good elasticity and chew ability and abundant availability of wheat grain can act as a potential gum base for medicated chewing gum.
机译：尝试使用天然胶基糖浆配制含药口香糖以防止晕动病，以便在不接触水的情况下随时随地更快起效并易于给药。为了避免口香糖的丢弃问题，由于其可生物降解和生物相容性且易于获得，研究了普通小麦（小麦粒）的胶基糖基础剂。从小麦中提取的醇溶蛋白具有良好的咀嚼能力，弹性，高保水能力，抗真菌活性以及与药物的相容性。基于两因素和三水平的析因设计来制备制剂。选择碳酸钙（膨化剂）和胶基的量作为自变量。弹性和药物释放被认为是因变量。评价所有批次的含量均匀性，弹性研究，质地研究，体外药物释放研究和咀嚼性研究。结果表明，含80 mg碳酸钙和500 mg胶基的药用口香糖在16分钟内显示出良好的弹性和90％以上的药物释放。因此，这项研究表明，良好的弹性和咀嚼能力以及充足的小麦籽粒可作为药用口香糖的潜在胶基。

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