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DNA Vaccination of American Robins (Turdus migratorius) Against West Nile Virus

机译：美国知更鸟（Turdus migratorius）对西尼罗河病毒的DNA疫苗接种

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West Nile virus (WNV) has caused at least 1150 cases of encephalitis, 100 deaths, and an estimated 30,000–80,000 illnesses in 6 of the last 7 years. Recent evidence from several regions has implicated American robins (Turdus migratorius) as an important host for feeding by Culex mosquitoes, and, when integrated with their host competence for WNV, demonstrates that they are a key WNV amplification host. We evaluated the efficacy of a DNA plasmid vaccine at reducing the viremia and infectiousness of hatch-year American robins. We found that a single dose of vaccine injected intramuscularly resulted in more than a 400-fold (102.6) decrease in average viremia. Although sample sizes were small, these results suggest that vaccinated robins exhibit viremias that are likely to be mostly noninfectious to biting Culex mosquitoes. More broadly, if an orally effective formulation of this vaccine could be developed, new control strategies based on wildlife vaccination may be possible.
机译：在过去的7年中，西尼罗河病毒（WNV）已导致至少1150例脑炎，100例死亡和大约30,000-80,000例疾病。来自几个地区的最新证据表明，美国知更鸟（Turdus migratorius）是库蚊（Culex蚊）摄食的重要宿主，并且与它们的WNV宿主能力整合后，证明它们是关键的WNV扩增宿主。我们评估了一种DNA质粒疫苗在降低孵化年美国知更鸟的病毒血症和传染性方面的功效。我们发现，肌肉内注射单剂疫苗可使平均病毒血症降低400倍以上（10 2.6 ）。尽管样本量很小，但这些结果表明，已接种疫苗的知更鸟表现出病毒血症，这种病毒血症对咬死库蚊的感染几乎没有感染力。更广泛地讲，如果可以开发出这种疫苗的口服有效制剂，那么基于野生动植物疫苗接种的新控制策略就可能成为可能。

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