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首页> 美国卫生研究院文献>Oncology Letters >Potential enhancement of intravenous nano-hydroxyapatite in high-intensity focused ultrasound ablation for treating hepatocellular carcinoma in a rabbit model
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Potential enhancement of intravenous nano-hydroxyapatite in high-intensity focused ultrasound ablation for treating hepatocellular carcinoma in a rabbit model

机译：高强度聚焦超声消融术中静脉内纳米羟基磷灰石治疗兔模型的潜力

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The aim of the present study was to evaluate the safety and efficiency of an intravenously delivered nano-hydroxyapatite (Nano-HA) solution into a rabbit model (Oryctolagus cuniculus) to determine the potential enhancement of high-intensity focused ultrasound (HIFU) for the ablation of hepatocellular carcinoma (HCC) in liver tissue. The present study clearly indicated that the intravenous delivery of large quantities of Nano-HA into the body of the rabbit model over relatively short periods of time may be absorbed by the hepatic reticuloendothelial system. Subsequent HIFU treatment for HCC, as well as intravenous Nano-HA, produced a rapid increase in temperature and an enlargement of the coagulated necrotic area during ablation in the in vivo and ex vivo environments. In addition, it was found that the therapeutic doses of Nano-HA produced mild and transient abnormalities in the normal renal function and hepatic enzymes during the first 24 h following administration. The results of the current study indicated that the combination of Nano-HA and HIFU may provide a safe and effective alternative to conventional surgical procedures.
机译：本研究的目的是评估静脉内递送的纳米羟基磷灰石（Nano-HA）溶液进入兔模型（Cryctolagus cuniculus）的安全性和效率，以确定高强度聚焦超声（HIFU）的潜在增强作用。消融肝组织中的肝细胞癌（HCC）。本研究清楚地表明，肝网状内皮系统可以在较短的时间内将大量的纳米HA静脉内输送到兔模型体内。随后的HIFU HCC治疗以及静脉内Nano-HA治疗，在体内和离体环境中进行消融过程中，温度迅速升高，凝固坏死区域扩大。另外，发现在给药后的最初24小时内，纳米HA的治疗剂量在正常的肾功能和肝酶中产生轻度和短暂的异常。目前的研究结果表明，纳米HA和HIFU的结合可以为常规外科手术提供安全有效的替代方案。

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