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首页> 美国卫生研究院文献>Scientific Reports >Peripheral CD39-expressing T regulatory cells are increased and associated with relapsing-remitting multiple sclerosis in relapsing patients
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Peripheral CD39-expressing T regulatory cells are increased and associated with relapsing-remitting multiple sclerosis in relapsing patients

机译：复发性患者中表达CD39的外周血T调节细胞增加并与复发性多发性硬化症相关

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CD39, an ectonucleotidase that hydrolyses pro-inflammatory ATP, is a marker of highly active and suppressive T regulatory cells (Tregs). Although CD39 has a role in Treg suppression and might be important in the control of neuroinflammation in relapsing-remitting multiple sclerosis (RR-MS), to date, there are contradictory reports concerning the Tregs expression of CD39 in RR-MS patients. Thus, our objectives were to assess the activity and expression of CD39, especially in Tregs from peripheral blood mononuclear cells (PBMCs) of relapsing RR-MS patients compared with control subjects and to evaluate the association of CD39+ Tregs with disability and the odds of RR-MS. The activity and expression of CD39 and the CD39+ Treg frequency were measured in PBMCs from 55 relapsing RR-MS patients (19 untreated and 36 receiving immunomodulatory treatment) and 55 age- and sex-paired controls. Moreover, the association between CD39+ Tregs and RR-MS was assessed by multivariate logistic regression. CD39 activity and the frequency of CD39-expressing Tregs were elevated in relapsing RR-MS patients. Moreover, CD39+ Tregs were significantly correlated with the EDSS score and were independently associated with the odds of RR-MS. Our results highlight the relevance of CD39+ Treg subset in the clinical outcomes of RR-MS.
机译：CD39是一种水解促炎性ATP的胞外核苷酸酶，是高度活跃和抑制性T调节细胞（Tregs）的标记。尽管CD39在Treg抑制中起作用，并且可能在复发-缓解型多发性硬化症（RR-MS）的神经炎症控制中起重要作用，但迄今为止，关于RR-MS患者CD39的Tregs表达的报道相互矛盾。因此，我们的目标是评估CD39的活性和表达，尤其是在复发性RR-MS患者外周血单核细胞（PBMC）的Treg与对照组相比，以及评估CD39 + Treg与残疾和RR的可能性之间的关系。 -多发性硬化症。在55名复发的RR-MS患者（19名未接受治疗的患者和36名接受免疫调节治疗的患者）和55名年龄和性别配对的对照组的PBMC中测量了CD39的活性和表达以及CD39 + Treg频率。此外，CD39 + Tregs与RR-MS之间的关联通过多因素logistic回归进行评估。在复发的RR-MS患者中，CD39活性和表达CD39的Treg的频率升高。此外，CD39 + Tregs与EDSS评分显着相关，并且与RR-MS的几率独立相关。我们的结果强调了CD39 + Treg亚群在RR-MS临床结果中的相关性。

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