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首页> 美国卫生研究院文献>Scientific Reports >Age-dependent changes in cardiac performance motor function QoL and mental status in metoprolol-treated chronic heart failure patients
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Age-dependent changes in cardiac performance motor function QoL and mental status in metoprolol-treated chronic heart failure patients

机译：美托洛尔治疗的慢性心力衰竭患者心脏性能运动功能生活质量和精神状态的年龄依赖性变化

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No previous study reports the effect of age on cardiac performance, motor function and quality of life (QoL) in Chinese chronic heart failure (CHF) patients. This single-center, prospective study enrolled CHF patients with resting heart rate (RHR) > 80 bpm, who were treated with metoprolol and were followed up at 1, 3, 6, and 12 months. Changes in cardiac, motor, and QoL parameters between patients aged ≥60 years and those aged <60 years were compared at all time points. P < 0.05 was considered significant. A total of 154 patients were enrolled (median age: 66.39 years; 116 aged ≥60 years, 38 aged <60 years; 95% New York Heart Association class III-IV). RHR decreased significantly in both patient groups (P < 0.0001 for both groups). Patients aged ≥60 years had a significant improvement in both ejection fraction (EF) at 6 and 12 months and in cardiac index (CI) at 3, 6, and 12 months. However, no major difference was observed in motor function in both groups. Significantly higher SF-8 scores showed greater improvement in QoL in the <60 age group at 12 months (P = 0.0008). Metoprolol demonstrated improvement in cardiac performance, motor function, QoL, and anxiety with increase in depression and burnout in both genders; however, the findings were independent of age.
机译：以前没有研究报告年龄对中国慢性心力衰竭（CHF）患者的心脏功能，运动功能和生活质量（QoL）的影响。这项单中心，前瞻性研究招募了静息心率（RHR）> 80 bpm的CHF患者，接受美托洛尔治疗，并在第1、3、6和12个月进行随访。在所有时间点比较≥60岁患者和<60岁患者的心脏，运动和QoL参数的变化。 P <0.05被认为是显着的。共有154名患者入选（中位年龄：66.39岁； 116岁≥60岁，38岁<60岁； 95％纽约心脏协会III-IV级）。两组患者的RHR均显着下降（两组P 0.0001）。 ≥60岁的患者在6和12个月时射血分数（EF）以及在3、6和12个月时心脏指数（CI）都有明显改善。然而，两组的运动功能均未见明显差异。在<60岁年龄组中，在12个月时，较高的SF-8分数显着提高了QoL（P = 0.0008）。美托洛尔在男女的抑郁和倦怠方面均表现出改善的心脏功能，运动功能，生活质量和焦虑。但是，调查结果与年龄无关。

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