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首页> 美国卫生研究院文献>Scientific Reports >Comparison of diffusion-weighted MRI and anti-Stokes Raman scattering (CARS) measurements of the inter-compartmental exchange-time of water in expression-controlled aquaporin-4 cells
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Comparison of diffusion-weighted MRI and anti-Stokes Raman scattering (CARS) measurements of the inter-compartmental exchange-time of water in expression-controlled aquaporin-4 cells

机译：在表达控制的Aquaporin-4细胞中水的小室间交换时间的扩散加权MRI和抗斯托克斯拉曼散射（CARS）测量的比较

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摘要

We performed multi-b and multi-diffusion-time diffusion-weighted magnetic resonance imaging on aquaporin-4-expressing (AQ) and -non-expressing (noAQ) cells, and demonstrated a clear difference between the signals from the two cell types. The data were interpreted using a two-compartment (intra and extracellular spaces) model including inter-compartmental exchange. It was also assumed that restricted diffusion of water molecules inside the cells leads to the intracellular diffusion coefficient being inversely proportional to the diffusion-time. Estimates of the water-exchange-times obtained with this model are compared to those measured using an independent optical imaging technique (coherent anti-Stokes Raman scattering imaging, CARS). For both techniques it was found that the exchange-time estimated for the noAQ cells was significantly longer than that for the AQ cells.
机译：我们对表达aquaporin-4（AQ）和-非表达（noAQ）的细胞进行了多次扩散和多次扩散加权磁共振成像，并证明了两种细胞信号之间的明显差异。使用包括隔室间交换的两隔室（细胞内和细胞外空间）模型解释数据。还假定水分子在细胞内的受限扩散导致细胞内扩散系数与扩散时间成反比。用该模型获得的水交换时间的估计值与使用独立光学成像技术（相干反斯托克斯拉曼散射成像，CARS）测量的值进行比较。对于这两种技术，发现noAQ细胞的估计交换时间明显长于AQ细胞的交换时间。

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