• 主题
高级搜索  >
历史搜索 清空历史
首页> 美国卫生研究院文献>Oncology Letters >Analysis of the efficacy of intensity-modulated radiotherapy and two-dimensional conventional radiotherapy in nasopharyngeal carcinoma with involvement of the cervical spine
【2h】

Analysis of the efficacy of intensity-modulated radiotherapy and two-dimensional conventional radiotherapy in nasopharyngeal carcinoma with involvement of the cervical spine

机译：调强放疗和二维常规放疗对鼻咽癌累及颈椎的疗效分析

代理获取
本网站仅为用户提供外文OA文献查询和代理获取服务，本网站没有原文。下单后我们将采用程序或人工为您竭诚获取高质量的原文，但由于OA文献来源多样且变更频繁，仍可能出现获取不到、文献不完整或与标题不符等情况，如果获取不到我们将提供退款服务。请知悉。
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

The aim of the present study was to retrospectively analyze the clinical efficacy and side-effects of two-dimensional conventional radiotherapy (2D-CRT) and intensity-modulated radiotherapy (IMRT) in 53 NPC patients with cervical spine involvement, without distant metastases. In total, 53 patients were enrolled in the present study, with 24 being treated with IMRT and 29 being treated with 2D-CRT. All 53 patients received platinum-based concurrent chemotherapy and 4–6 cycles of adjuvant chemotherapy subsequent to radiation. The patients were clinically staged according to the seventh edition of the UICC and AJCC staging systems. Overall survival (OS), local progression-free survival (LPFS) and distant metastasis-free survival (DMFS) rates were calculated. The 3- and 5-year OS rates were 87.7% and 45.5% in the IMRT-treated group and 65.5% and 9.1% in the 2D-CRT-treated group (P=0.01). The 3- and 5-year LPES rates were 87.4% and 69.9% in the IMRT-treated group compared with 49.4% and 9.4% in the 2D-CRT-treated group, respectively (P=0.00). The 3- and 5-year DMFS rates were 94.4 and 40.8% in the IMRT-treated group and 79.8 and 30.4% in the 2D-CRT-treated group (P=0.13). N stage (P=0.00) and radiotherapy methods (P=0.01) were relevant to the OS and LPFS rates, it also revealed a significant difference when the DMFS rates were analyzed in N stage. The incidence of dry mouth in the IMRT group was significantly lower (P=0.01), but there was no statistically significant difference in acute oropharyngeal mucositis or myelosuppression. IMRT had significant advantages in local control and OS compared with conventional 2D-CRT, but IMRT failed to reduce the incidence of distant metastasis.
机译：本研究的目的是回顾性分析53例NPC颈椎受累无远处转移的NPC患者的二维常规放疗（2D-CRT）和强度调节放疗（IMRT）的临床疗效和副作用。本研究共纳入53位患者，其中24例接受IMRT治疗，29例接受2D-CRT治疗。所有53例患者在放疗后均接受了铂类同时化疗和4–6周期的辅助化疗。根据UICC和AJCC分期系统的第七版对患者进行临床分期。计算总生存期（OS），局部无进展生存期（LPFS）和远处无转移生存期（DMFS）率。 IMRT治疗组的3年和5年OS率分别为87.7％和45.5％，而2D-CRT治疗组的3年和5年OS率分别为65.5％和9.1％（P = 0.01）。 IMRT治疗组的3年和5年LPES发生率分别为87.4％和69.9％，而2D-CRT治疗组分别为49.4％和9.4％（P = 0.00）。 IMRT治疗组的3年和5年期DMFS发生率分别为94.4和40.8％，而2D-CRT治疗组为79.8和30.4％（P = 0.13）。 N期（P = 0.00）和放疗方法（P = 0.01）与OS和LPFS发生率相关，在N期分析DMFS发生率也显示出显着差异。 IMRT组口干的发生率显着降低（P = 0.01），但是急性口咽粘膜炎或骨髓抑制没有统计学意义的差异。与传统的2D-CRT相比，IMRT在局部控制和OS方面具有显着优势，但是IMRT未能减少远处转移的发生率。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
代理获取

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号