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首页> 美国卫生研究院文献>Nature Communications >NIR-light-mediated spatially selective triggering of anti-tumor immunity via upconversion nanoparticle-based immunodevices
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NIR-light-mediated spatially selective triggering of anti-tumor immunity via upconversion nanoparticle-based immunodevices

机译：通过基于上转换的纳米粒子的免疫装置的近红外光介导的空间选择性触发抗肿瘤免疫

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Immunomodulatory therapies are becoming a paradigm-shifting treatment modality for cancer. Despite promising clinical results, cancer immunotherapy is accompanied with off-tumor toxicity and autoimmune adverse effects. Thus, the development of smarter systems to regulate immune responses with superior spatiotemporal precision and enhanced safety is urgently needed. Here we report an activatable engineered immunodevice that enables remote control over the antitumor immunity in vitro and in vivo with near-infrared (NIR) light. The immunodevice is composed of a rationally designed UV light-activatable immunostimulatory agent and upconversion nanoparticle, which acts as a transducer to shift the light sensitivity of the device to the NIR window. The controlled immune regulation allows the generation of effective immune response within tumor without disturbing immunity elsewhere in the body, thereby maintaining the antitumor efficacy while mitigating systemic toxicity. The present work illustrates the potential of the remote-controlled immunodevice for triggering of immunoactivity at the right time and site.
机译：免疫调节疗法正在成为癌症的范式转变疗法。尽管取得了令人鼓舞的临床结果，但癌症免疫疗法仍伴随着肿瘤外毒性和自身免疫性不良反应。因此，迫切需要开发更智能的系统来以更高的时空精度和增强的安全性来调节免疫反应。在这里，我们报告了一种可激活的工程免疫设备，该设备可通过近红外（NIR）光在体外和体内远程控制抗肿瘤免疫力。免疫装置由合理设计的紫外线可激活的免疫刺激剂和上转换纳米粒子组成，该纳米粒子充当将装置的光敏性转移到NIR窗口的换能器。受控的免疫调节允许在肿瘤内产生有效的免疫反应而不会干扰身体其他部位的免疫，从而在降低全身毒性的同时保持抗肿瘤功效。本工作说明了遥控免疫设备在正确的时间和地点触发免疫活性的潜力。

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