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首页> 美国卫生研究院文献>Oncology Letters >Extracts of centipede Scolopendra subspinipes mutilans induce cell cycle arrest and apoptosis in A375 human melanoma cells
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Extracts of centipede Scolopendra subspinipes mutilans induce cell cycle arrest and apoptosis in A375 human melanoma cells

机译：mScolopendra亚纺锤体提取物诱导人A375黑色素瘤细胞的细胞周期停滞和凋亡

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摘要

Extracts from the centipede Scolopendra genus, have been used in traditional medicine for the treatment of various diseases and have been found to exhibit anticancer activity in tumor cells. To investigate the potential and associated antitumor mechanism of alcohol extracts of the centipede Scolopendra subspinipes mutilans (AECS), cell viability, cell cycle and cell apoptosis were studied and the results revealed that AECS inhibits A375 cell proliferation in a dose- and time-dependent manner. In addition, AECS was found to arrest the cell cycle of A375 cells at the S phase, which was accompanied by a marked increase in the protein levels of cyclin E and a decrease in the protein levels of cyclin D1. In a cell culture system, AECS markedly induced the apoptosis of A375 cells, which was closely associated with the effects on the Bcl-2 family, whereby decreased Bcl-2 and increased Bak, Bax and Bad expression levels were observed. The underlying mechanism of AECS inhibiting A375 cell proliferation was associated with the induction of cell cycle arrest and apoptosis, indicating that AECS may present as a potential therapeutic agent for administration in human melanoma cancer intervention.
机译：SScolopendra属的提取物已用于传统医学中，用于治疗各种疾病，并已发现其在肿瘤细胞中具有抗癌活性。为研究mScolopendra subspinipes mutilans（AECS）乙醇提取物的潜力和相关的抗肿瘤机制，研究了细胞活力，细胞周期和细胞凋亡，结果表明，AECS以剂量和时间依赖性方式抑制A375细胞增殖。此外，发现AECS使A375细胞的细胞周期停滞在S期，并伴随着细胞周期蛋白E蛋白水平的显着增加和细胞周期蛋白D1蛋白水平的下降。在细胞培养系统中，AECS明显诱导A375细胞凋亡，这与对Bcl-2家族的影响密切相关，从而观察到Bcl-2减少和Bak，Bax和Bad表达水平升高。 AECS抑制A375细胞增殖的潜在机制与诱导细胞周期停滞和凋亡有关，这表明AECS可能作为潜在的治疗剂用于人黑素瘤癌症干预。

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