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首页> 美国卫生研究院文献>Oncology Letters >Correlation among 16 biological factors p53 p21waf1 MIB-1 (Ki-67) p16INK4A cyclin D1 E-cadherin Bcl-2 TNF-α NF-κB TGF-β MMP-7 COX-2 EGFR HER2eu ER and HIF-1α and clinical outcomes following curative chemoradiation therapy in 10 patients with esophageal squamous cell carcinoma
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Correlation among 16 biological factors p53 p21waf1 MIB-1 (Ki-67) p16INK4A cyclin D1 E-cadherin Bcl-2 TNF-α NF-κB TGF-β MMP-7 COX-2 EGFR HER2eu ER and HIF-1α and clinical outcomes following curative chemoradiation therapy in 10 patients with esophageal squamous cell carcinoma

机译：16种生物学因子p53p21waf1MIB-1（Ki-67）p16INK4Acyclin D1E-cadherinBcl-2TNF-αNF-κBTGF-βMMP-7COX- 2EGFRHER2 / neuER和HIF-1α与10例食管鳞癌根治性化学放射治疗后的临床结局

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The expression levels of 16 proteins were analyzed to identify prognostic correlations in esophageal squamous cell carcinoma (ESCC) treated with concurrent chemoradiation therapy (CCRT). The immunohistochemical expression levels of p53, p21waf1, molecular immunology borstel-1 (MIB-1, Ki-67), p16INK4A, cyclin D1, E-cadherin, Bcl-2, tumor necrosis factor (TNF)-α, nuclear factor (NF)-κB, transforming growth factor (TGF)-β, matrix metalloproteinase (MMP)-7, cyclooxygenase (COX)-2, epidermal growth factor receptor (EGFR), human EGFR type 2 (HER2eu), estrogen receptor (ER) and hypoxia-inducible factor (HIF)-1α were studied in 10 cases of ESCC treated with CCRT. The patients underwent CCRT between 2000 and 2010. The mean patient age was 68.1 years (range, 46-80 years). The numbers of patients in stages I, II, III and IV of the disease were 2, 2, 3 and 3, respectively. Of the tumors, 8 were positive for p53, 6 for p21waf1, 7 for MIB-1 (Ki-67), 7 for p16INK4A, 7 for cyclin D1, 8 for E-cadherin, 3 for Bcl-2, 0 for TNF-α, 5 for NF-κB, 7 for TGF-β, 9 for MMP-7, 7 for COX-2, 5 for EGFR, 1 for HER2eu, 1 for ER and 7 for HIF-1α. The 2-year overall survival rate of patients expressing high levels of MIB-1 was 71% (±17%) compared with 0% (P=0.019) for those expressing low levels. For NF-κB, the rate was 0% for patients with high levels compared with 100% (P<0.018) for those with low levels. The 2-year local control rates of HER2eu were 0% in patients expressing high levels and 88% (±12%) in patients expressing low levels (P=0.027). The 2-year disease-free survival rates of HER2eu and ER were 0% for patients expressing high levels compared with 56% (±17%) for those with low levels (P=0.027). There were no significant correlations between the expression levels of the other proteins and clinical outcomes. In the present study, high levels of MIB-1 and low levels of NF-κB, HER2 and ER were shown to be good prognostic factors following definitive CCRT for ESCC.
机译：分析了16种蛋白的表达水平，以确定经同时放化疗的食管鳞状细胞癌（ESCC）的预后相关性。 p53，p21 waf1 ，分子免疫学borstel-1（MIB-1，Ki-67），p16 INK4A ，细胞周期蛋白D1，E-钙黏着蛋白，Bcl的免疫组化表达水平-2，肿瘤坏死因子（TNF）-α，核因子（NF）-κB，转化生长因子（TGF）-β，基质金属蛋白酶（MMP）-7，环氧合酶（COX）-2，表皮生长因子受体（EGFR） ），在10例接受CCRT治疗的ESCC患者中研究了人类EGFR 2型（HER2 / neu），雌激素受体（ER）和缺氧诱导因子（HIF）-1α。患者在2000年至2010年间接受了CCRT。患者平均年龄为68.1岁（范围46-80岁）。在该疾病的I，II，III和IV期的患者人数分别为2、2、3和3。在这些肿瘤中，p53阳性8例，p21 waf1 6例，MIB-1（Ki-67）7 ，p16 INK4A 7，细胞周期蛋白D1 7， E-钙粘蛋白8，Bcl-2 3，TNF-α0，NF-κB5，TGF-β7，MMP-7 9，COX-2 7，EGFR 5，HER2 / 1 neu，ER表示1，HIF-1α表示7。高水平MIB-1患者的2年总生存率为71％（±17％），而低水平MIB-1患者为2％（P = 0.019）。高水平患者的NF-κB发生率为0％，低水平患者为10​​0％（P <0.018）。 HER2 / neu的2年局部控制率在高水平患者中为0％，在低水平患者中为88％（±12％）（P = 0.027）。高水平患者的2年无病生存率HER2 / neu和ER为0％，而低水平患者为56％（±17％）（P = 0.027）。其他蛋白质的表达水平与临床结果之间无显着相关性。在本研究中，高水平的MIB-1和低水平的NF-κB，HER2和ER被证明是对ESCC进行明确CCRT后的良好预后因素。

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