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首页> 美国卫生研究院文献>Scientific Reports >Red algal extracts from Plocamium lyngbyanum and Ceramium secundatum stimulate osteogenic activities in vitro and bone growth in zebrafish larvae
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Red algal extracts from Plocamium lyngbyanum and Ceramium secundatum stimulate osteogenic activities in vitro and bone growth in zebrafish larvae

机译：紫草和沙地柏的红色藻类提取物在体外刺激成骨活性和斑马鱼幼虫的骨生长

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Through the current trend for bioprospecting, marine organisms - particularly algae - are becoming increasingly known for their osteogenic potential. Such organisms may provide novel treatment options for osteoporosis and other musculoskeletal conditions, helping to address their large healthcare burden and the limitations of current therapies. In this study, extracts from two red algae – Plocamium lyngbyanum and Ceramium secundatum – were tested in vitro and in vivo for their osteogenic potential. In vitro, the growth of human bone marrow stromal cells (hBMSCs) was significantly greater in the presence of the extracts, particularly with P. lyngbyanum treatment. Osteogenic differentiation was promoted more by C. secundatum (70 µg/ml), though P. lyngbyanum had greater in vitro mineralisation potential. Both species caused a marked and dose-dependent increase in the opercular bone area of zebrafish larvae. Our findings therefore indicate the presence of bioactive components in P. lyngbyanum and C. secundatum extracts, which can promote both in vitro and in vivo osteogenic activity.
机译：通过当前的生物勘探趋势，海洋生物尤其是藻类因其成骨潜力而越来越为人所知。这样的生物体可以为骨质疏松症和其他肌肉骨骼疾病提供新颖的治疗选择，有助于解决其庞大的医疗保健负担和当前疗法的局限性。在这项研究中，从体内和体外测试了两种红藻的提取物-Plocamium lyngbyanum和Ceramium secundatum-的成骨潜力。在体外，在有提取物存在的情况下，尤其是在P. lyngbyanum处理下，人骨髓基质细胞（hBMSCs）的生长明显更大。尽管C. lyngbyanum具有更大的体外矿化潜力，但C. secundatum（70？µg / ml）促进了成骨分化。两种物种都导致斑马鱼幼虫的眼部骨区域显着且剂量依赖性地增加。因此，我们的研究结果表明，P。lyngbyanum和C. secundatum提取物中存在生物活性成分，可以促进体外和体内成骨活性。

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