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Epidemics of HIV HCV and syphilis infection among synthetic drugs only users heroin-only users and poly-drug users in Southwest China

机译:中国西南地区仅合成药物使用者仅海洛因使用者和多药使用者中的HIVHCV和梅毒感染流行

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摘要

The number of poly-drug users who mix use heroin and synthetic drugs (SD) is increasing worldwide. The objective of this study is to measure the risk factors for being infected with hepatitis C (HCV), human immunodeficiency virus (HIV) and syphilis among SD-only users, heroin-only users and poly-drug users. A cross-sectional study was conducted in 2015 from a national HIV surveillance site in Southwest China, 447 poly-drug, 526 SD-only and 318 heroin-only users were recruited. Poly-drug users have higher drug-use frequency, higher rates of drug-sharing and unsafe sexual acts than other users (p < 0.05). About a third (36.7%) of poly-drug users experienced sexual arousal due to drug effects, which is higher than the rate among other drug users. Poly-drug users had the highest prevalence of HIV (10.5%) and syphilis (3.6%), but heroin-only users had the highest prevalence of HCV (66.0%) (all p < 0.05) among three groups. Logistic regression shows among poly-drug users, having sex following drug consumption and using drugs ≥1/day were the major risk factors for both HIV (Adjusted odds ratio (AOR) = 2.4, 95% CI [1.8–3.4]; 2.3, [1.6–3.1]) and syphilis infection (AOR = 4.1, [2.1–6.9]; 3.9, [1.8–5.4]). Elevated risk of both HIV and syphilis infection have been established among poly-drug users.
机译:在全球范围内,混合使用海洛因和合成毒品(SD)的多药使用者数量正在增加。这项研究的目的是在仅使用SD的用户,仅使用海洛因的用户和使用多种药物的用户中测量感染丙型肝炎(HCV),人免疫缺陷病毒(HIV)和梅毒的危险因素。 2015年,在中国西南部的国家艾滋病毒监测点进行了一项横断面研究,招募了447种多药,仅526种SD和318种海洛因使用者。与其他使用者相比,使用多种毒品的使用者吸毒的频率更高,分享毒品的比率更高,发生不安全的性行为(p <0.05)。约有三分之一(36.7%)的多药使用者由于吸毒而遭受性唤起,这一比例高于其他吸毒者。在三组中,多药使用者的HIV和梅毒患病率最高(10.5%)和梅毒(3.6%),而仅海洛因使用者的HCV患病率最高(66.0%)(所有p <0.05)。 Logistic回归显示,在多药使用者中,服药后发生性行为和每天使用≥1天的药物是两种HIV的主要危险因素(校正比值比(AOR)= 2.4,95%CI [1.8-3.4]; 2.3, [1.6–3.1])和梅毒感染(AOR = 4.1,[2.1-6.9]; 3.9,[1.8-5.4])。在多药使用者中已经确定了艾滋病毒和梅毒感染的风险增加。

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