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Coupled symmetric and asymmetric circuits underlying spatial orientation in fruit flies

机译:果蝇空间定向下的对称和非对称耦合电路

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摘要

Maintaining spatial orientation when carrying out goal-directed movements requires an animal to perform angular path integration. Such functionality has been recently demonstrated in the ellipsoid body (EB) of fruit flies, though the precise circuitry and underlying mechanisms remain unclear. We analyze recently published cellular-level connectomic data and identify the unique characteristics of the EB circuitry, which features coupled symmetric and asymmetric rings. By constructing a spiking neural circuit model based on the connectome, we reveal that the symmetric ring initiates a feedback circuit that sustains persistent neural activity to encode information regarding spatial orientation, while the asymmetric rings are capable of integrating the angular path when the body rotates in the dark. The present model reproduces several key features of EB activity and makes experimentally testable predictions, providing new insight into how spatial orientation is maintained and tracked at the cellular level.
机译:进行目标定向的运动时,要保持空间定向,就需要动物进行角路径整合。这种功能最近在果蝇的椭圆体(EB)中得到了证明,尽管确切的电路和潜在的机制尚不清楚。我们分析了最近发表的细胞水平的组学数据,并确定了具有对称和不对称环耦合的EB电路的独特特征。通过建立基于连接体的尖峰神经回路模型,我们发现对称环会启动一个反馈电路,该回路维持持续的神经活动以编码有关空间方向的信息,而非对称环能够在人体旋转时整合角路径。黑暗。本模型再现了EB活性的几个关键特征,并进行了可实验测试的预测,从而提供了有关如何在细胞水平上维持和跟踪空间定向的新见识。

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