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首页> 美国卫生研究院文献>Scientific Reports >Evaluation of the therapeutic effects of QuickOpt optimization in Chinese patients with chronic heart failure treated by cardiac resynchronization
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Evaluation of the therapeutic effects of QuickOpt optimization in Chinese patients with chronic heart failure treated by cardiac resynchronization

机译：快速同步优化技术在中国慢性心力衰竭患者心脏再同步治疗中的疗效评价

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In this trial, long-term therapeutic effects and clinical improvements in Chinese chronic heart failure patients optimized by QuickOpt or echocardiography were compared for atrioventricular (AV) and interventricular (VV) delay optimizations after cardiac resynchronization therapy (CRT) with pacing (CRT-P) or with pacing and defibrillator (CRT-D) therapy. One hundred and ninety-six subjects (50%) had dilated cardiomyopathy, 108 (27.6%) had ischemic heart disease and 112 (28.6%) were hypertensive and were randomized into QuickOpt (198) or echocardiographic optimization (control) (194) groups at ≤2-weeks post-implantation. Programmed AV/VV delay was optimized at baseline and at 3 and 6 months. Left ventricular end-systolic volume (LVESV), New York Heart Association (NYHA) class, specific activity scale (SAS), and the six-minute walk tests (6MWT) were evaluated by blinded researchers at 12 months. Of the QuickOpt group, LVESV decreased significantly by 24.7% ± 33.9% compared with baseline, while LVESV of Controls decreased by 25.1% ± 36.1% (P = 0.924). NYHA class, SAS and 6MWT also improved similarly in both groups at 12 months. Mortality in both groups was not significantly different (11.0% vs 7.6%, P = 0.289). However, there was a significant difference in the time required for optimization by QuickOpt compared with echocardiography (3.33 ± 3.11 vs 58.79 ± 27.03 minutes, P < 0.000).
机译：在该试验中，比较了通过QuickOpt或超声心动图优化的中国慢性心力衰竭患者的长期治疗效果和临床改善情况，并进行了心脏同步治疗（CRT）和起搏（CRT-P）后的房室（AV）和心室（VV）延迟优化）或使用起搏和除颤器（CRT-D）治疗。 196名受试者（50％）患有扩张型心肌病，108名（27.6％）患有缺血性心脏病，112名（28.6％）患有高血压，被随机分为QuickOpt（198）或超声心动图优化（对照组）（194）组植入后≤2周。在基线，3个月和6个月时优化了程序化的AV / VV延迟。盲法研究人员在12个月时评估了左心室收缩末期容积（LVESV），纽约心脏协会（NYHA）类，比活动量表（SAS）和六分钟步行测试（6MWT）。在QuickOpt组中，与基线相比，LVESV显着下降了24.7％±33.9％，而对照组的LVESV则下降了25.1％±36.1％（P = 0.924）。在12个月时，两组的NYHA等级，SAS和6MWT也有类似的改善。两组的死亡率无显着差异（11.0％对7.6％，P = 0.289）。但是，与超声心动图相比，QuickOpt优化所需的时间有显着差异（3.33±3.11分钟对58.79±27.03分钟，P ＜0.000）。

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