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首页> 美国卫生研究院文献>Scientific Reports >N-Acetyl-Aspartate in the dorsolateral prefrontal cortex in men with schizophrenia and auditory verbal hallucinations: A 1.5 T Magnetic Resonance Spectroscopy Study
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N-Acetyl-Aspartate in the dorsolateral prefrontal cortex in men with schizophrenia and auditory verbal hallucinations: A 1.5 T Magnetic Resonance Spectroscopy Study

机译：精神分裂症和听觉言语幻觉的男性背外侧前额叶皮层中的N-乙酰天门冬氨酸：1.5 T磁共振波谱研究

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摘要

Auditory verbal hallucinations (AVH) in patients with schizophrenia are linked to abnormalities within a large cerebral network including frontal and temporal regions. Whilst abnormalities of frontal speech production and temporal speech perception regions have been extensively studied, alterations of the dorsolateral prefrontal cortex (DLPFC), a region critically involved in the pathophysiology of schizophrenia, have rarely been studied in relation to AVH. Using 1.5 T proton magnetic resonance spectroscopy, this study examined the relationship between right and left DLPFCs N-AcetylAspartate (NAA) levels and the severity of AVH in patients with schizophrenia. Twenty-seven male patients with schizophrenia were enrolled in this study, 15 presented daily treatment-resistant AVH (AVH+) and 12 reported no AVH (no-AVH). AVH+ patients displayed higher NAA levels in the right DLPFC than no-AVH patients (p = 0.033). In AVH+ patients, NAA levels were higher in the right DLPFC than in the left (p = 0.024). No difference between the right and left DLPFC was observed in no-AVH patients. There was a positive correlation between NAA levels in the right DLPFC and the severity of AVH (r = 0.404, p = 0.037). Despite limited by magnetic field strength, these results suggest that AVH may be associated with increased NAA levels in the right DLPFC in schizophrenia.
机译：精神分裂症患者的听觉言语幻觉（AVH）与包括额叶和颞叶区域在内的大型大脑网络中的异常有关。尽管已经广泛研究了额叶语音产生和颞叶语音感知区域的异常，但很少研究与精神分裂症的病理生理有关的背外侧前额叶皮层（DLPFC）的改变。本研究使用1.5 proT质子磁共振波谱，研究了精神分裂症患者左右DLPFCs N-乙酰天门冬氨酸（NAA）水平与AVH严重程度之间的关系。这项研究招募了27位男性精神分裂症男性患者，其中15例每天出现抗药性AVH（AVH +），12例未报告抗AVH（no-AVH）。 AVH +患者在右DLPFC中显示的NAA水平高于非AVH患者（p = 0.033）。在AVH +患者中，右DLPFC中的NAA水平高于左中（p levels = 0.024）。在没有AVH的患者中，左右DLPFC之间没有差异。右侧DLPFC中的NAA水平与AVH的严重程度呈正相关（r = 0.404，p = 0.037）。尽管受到磁场强度的限制，但这些结果表明，AVH可能与精神分裂症患者右DLPFC中的NAA水平升高有关。

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