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首页> 美国卫生研究院文献>Scientific Reports >The impact of computed high b-value images on the diagnostic accuracy of DWI for prostate cancer: A receiver operating characteristics analysis
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The impact of computed high b-value images on the diagnostic accuracy of DWI for prostate cancer: A receiver operating characteristics analysis

机译：计算的高b值图像对DWI对前列腺癌的诊断准确性的影响：接收器工作特性分析

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To evaluate the performance of computed high b value diffusion-weighted images (DWI) in prostate cancer detection. 97 consecutive patients who had undergone multiparametric MRI of the prostate followed by biopsy were reviewed. Five radiologists independently scored 138 lesions on native high b-value images (b = 1200 s/mm2), apparent diffusion coefficient (ADC) maps, and computed high b-value images (contrast equivalent to b = 2000 s/mm2) to compare their diagnostic accuracy. Receiver operating characteristic (ROC) analysis and McNemar’s test were performed to assess the relative performance of computed high b value DWI, native high b-value DWI and ADC maps. No significant difference existed in the area under the curve (AUC) for ROCs comparing B1200 (b = 1200 s/mm2) to computed B2000 (c-B2000) in 5 readers. In 4 of 5 readers c-B2000 had significantly increased sensitivity and/or decreased specificity compared to B1200 (McNemar’s p < 0.05), at selected thresholds of interpretation. ADC maps were less accurate than B1200 or c-B2000 for 2 of 5 readers (P < 0.05). This study detected no consistent improvement in overall diagnostic accuracy using c-B2000, compared with B1200 images. Readers detected more cancer with c-B2000 images (increased sensitivity) but also more false positive findings (decreased specificity).
机译：为了评估前列腺癌检测中计算出的高b值扩散加权图像（DWI）的性能。回顾了连续97例接受了前列腺多参数MRI活检的患者。五名放射科医生在本机高b值图像（b = 1200 s / mm 2 ），视扩散系数（ADC）图和计算出的高b值图像（与b = 2000 s / mm 2 ）以比较其诊断准确性。进行了接收机工作特性（ROC）分析和McNemar测试，以评估计算出的高b值DWI，原始高b值DWI和ADC映射的相对性能。在5个阅读器中，将B1200（b = 1200 s / mm 2 ）与计算的B2000（c-B2000）进行比较，ROC的曲线下面积（AUC）没有显着差异。在选定的解释阈值下，与B1200相比，c-B2000中有4个读者的敏感性和/或特异性明显降低（McNemar的p <0.05）。对于5个阅读器中的2个，ADC映射的准确性低于B1200或c-B2000（P <0.05）。这项研究发现，与B1200图像相比，使用c-B2000的总体诊断准确性没有持续改善。读者使用c-B2000图像检测到更多的癌症（灵敏度提高），但也发现了更多的假阳性结果（特异性降低）。

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