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首页> 美国卫生研究院文献>Scientific Reports >A fluidic device for the controlled formation and real-time monitoring of soft membranes self-assembled at liquid interfaces
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A fluidic device for the controlled formation and real-time monitoring of soft membranes self-assembled at liquid interfaces

机译：用于控制在液体界面上自组装的软膜的形成和实时监控的流体装置

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摘要

Membrane materials formed at the interface between two liquids have found applications in a large variety of technologies, from sensors to drug-delivery and catalysis. However, studying the formation of these membranes in real-time presents considerable challenges, owing to the difficulty of prescribing the location and instant of formation of the membrane, the difficulty of observing time-dependent membrane shape and thickness, and the poor reproducibility of results obtained using conventional mixing procedures. Here we report a fluidic device that facilitates characterisation of the time-dependent thickness, morphology and mass transport properties of materials self-assembled at fluid-fluid interfaces. In the proposed device the membrane forms from the controlled coalescence of two liquid menisci in a linear open channel. The linear geometry and controlled mixing of the solutions facilitate real-time visualisation, manipulation and improve reproducibility. Because of its small dimensions, the device can be used in conjunction with standard microscopy methods and reduces the required volumes of potentially expensive reagents. As an example application to tissue engineering, we use the device to characterise interfacial membranes formed by supra-molecular self-assembly of peptide-amphiphiles with either an elastin-like-protein or hyaluronic acid. The device can be adapted to study self-assembling membranes for applications that extend beyond bioengineering.
机译：在两种液体之间的界面处形成的膜材料已在从传感器到药物输送和催化的多种技术中得到应用。然而，由于难以规定膜的位置和形成瞬间，难以观察随时间变化的膜形状和厚度以及结果的可再现性差，因此实时研究这些膜的形成提出了相当大的挑战。使用常规混合程序获得。在这里，我们报告了一种流体装置，该装置有助于表征随时间变化的厚度，形态和在流体-流体界面处自组装的材料的传质特性。在所提出的装置中，膜由线性开放通道中的两个液体弯液面的受控合并形成。溶液的线性几何形状和受控混合有助于实时可视化，处理并提高可重复性。由于其尺寸小，该设备可与标准显微镜方法结合使用，并减少了潜在昂贵试剂的所需体积。作为组织工程的一个示例应用，我们使用该设备来表征由弹性蛋白样蛋白或透明质酸的肽两亲分子的超分子自组装形成的界面膜。该设备可适用于研究自组装膜，其应用范围超出了生物工程领域。

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