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首页> 美国卫生研究院文献>Scientific Reports >Hyaluronic acid-based nano-sized drug carrier-containing Gellan gum microspheres as potential multifunctional embolic agent
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Hyaluronic acid-based nano-sized drug carrier-containing Gellan gum microspheres as potential multifunctional embolic agent

机译：含透明质酸的纳米级载药凝胶兰胶微球作为潜在的多功能栓塞剂

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The purpose of this study was to develop a gellan gum-based multifunctional embolic agent. Calibrated spherical gellan gum and nanoparticle-containing gellan gum microspheres were prepared via water-in oil emulsification method. Self-assembled nanoparticles composed of short-chain hyaluronic acid and polyethylenimine as the doxorubicin carrier were prepared. The short-chain hyaluronic acid/polyethylenimine/ doxorubicin (sHH/PH/Dox) with the mean size was 140 ± 8 nm. To examine sHH/PH/Dox nanoparticle uptake into cells, the results confirmed that sHH/PH nanoparticles as drug carrier can facilitate the transport of doxorubicin into HepG2 liver cancer cells. Subsequently, sHH/PH/Dox merged into the gellan gum (GG) microspheres forming GG/sHH/PH/Dox microsphere. After a drug release experiment lasting 45 days, the amount of released doxorubicin from 285, 388, and 481 μm GG/sHH/PH/Dox microspheres were approximately 4.8, 1.8 and 1.1-fold above the IC50 value of the HepG2 cell. GG/sHH/PH/Dox microspheres were performed in rabbit ear embolization model and ischemic necrosis on ear was visible due to the vascular after 8 days. Regarding the application of this device in the future, we aim to provide better embolization agents for transcatheter arterial chemoembolization (TACE).
机译：这项研究的目的是开发基于结冷胶的多功能栓塞剂。通过油包水乳化法制备了校准的球形吉兰糖胶和含纳米颗粒的吉兰糖胶微球。制备了由短链透明质酸和聚乙烯亚胺作为阿霉素载体的自组装纳米颗粒。短链透明质酸/聚乙烯亚胺/阿霉素（sHH / PH / Dox）的平均大小为140±8 nm。为了检查sHH / PH / Dox纳米颗粒对细胞的摄取，结果证实sHH / PH纳米颗粒作为药物载体可以促进阿霉素向HepG2肝癌细胞的转运。随后，sHH / PH / Dox合并到结冷胶（GG）微球中，形成GG / sHH / PH / Dox微球。经过持续45天的药物释放实验后，从285、388和481μmGG / sHH / PH / Dox微球释放的阿霉素的量比HepG2细胞的IC50值高约4.8、1.8和1.1倍。 GG / sHH / PH / Dox微球在兔耳栓塞模型中进行，8天后由于血管可见耳部缺血性坏死。关于将来该设备的应用，我们旨在为经导管动脉化学栓塞（TACE）提供更好的栓塞剂。

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