• 主题
高级搜索  >
历史搜索 清空历史
首页> 美国卫生研究院文献>Journal of Medical Toxicology >Plasma and Urine Dimercaptopropanesulfonate Concentrations after Dermal Application of Transdermal DMPS (TD-DMPS)
【2h】

Plasma and Urine Dimercaptopropanesulfonate Concentrations after Dermal Application of Transdermal DMPS (TD-DMPS)

机译：透皮DMPS（TD-DMPS）皮肤应用后的血浆和尿液中的巯基丙磺酸盐浓度

代理获取
本网站仅为用户提供外文OA文献查询和代理获取服务，本网站没有原文。下单后我们将采用程序或人工为您竭诚获取高质量的原文，但由于OA文献来源多样且变更频繁，仍可能出现获取不到、文献不完整或与标题不符等情况，如果获取不到我们将提供退款服务。请知悉。
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

2,3-Dimercaptopropane-1-sulfonate (DMPS) is a metal chelator approved in Europe for oral or intravenous use for heavy metal poisoning. Transdermally applied DMPS (TD-DMPS) is used by some alternative practitioners to treat autism, despite the absence of evidence for its efficacy. We found no literature evaluating the pharmacokinetics of the transdermal route of delivery or the ability of TD-DMPS to enhance urinary mercury elimination. We hypothesized that TD-DMPS is not absorbed. Eight adult volunteers underwent application of 1.5–3 drops/kg of TD-DMPS. Subjects provided 12-h urine collections the day before and day of application. Subjects underwent blood draws at 0, 30, 60,90, 120, and 240 min after TD-DMPS application. Plasma and urine were assayed for the presence of DMPS. Urine was assayed for any change in urinary mercury excretion after DMPS. One control subject ingested 250 mg of oral DMPS and underwent the same urine and blood collections and analyses. No subject had detectable urine DMPS or increased urine mercury excretion after TD-DMPS. One subject had detectable levels of DMPS in the 30-min plasma sample, suspected to be contamination. All other samples for that subject and the other seven subjects showed no detectable plasma DMPS. The control subject had detectable urine and plasma DMPS levels and increased urine mercury excretion. These results indicate that TD-DMPS is not absorbed. There was no increase in urine mercury excretion after TD-DMPS. Our results argue that TD-DMPS is an ineffective metal chelator.
机译：2,3-二巯基丙烷-1-磺酸盐（DMPS）是一种在欧洲获准用于口服或静脉内用于重金属中毒的金属螯合剂。尽管没有证据证明自闭症的有效性，但一些替代医师仍使用经皮施用的DMPS（TD-DMPS）来治疗自闭症。我们发现没有文献评估透皮给药途径的药代动力学或TD-DMPS增强尿液汞消除的能力。我们假设TD-DMPS没有被吸收。八名成年志愿者接受了每公斤TD-DMPS 1.5–3滴的应用。受试者在使用前一天和第二天提供了12小时尿液收集。 TD-DMPS施用后0、30、60、90、120和240分钟对受试者进行抽血。测定血浆和尿液中是否存在DMPS。在DMPS后，分析尿液中尿汞排泄的任何变化。一名对照组受试者摄入250 mg口服DMPS，并进行了相同的尿液和血液采集和分析。 TD-DMPS后没有受试者可检测到尿DMPS或尿汞排泄增加。一名受试者在30分钟的血浆样本中可检测到DMPS的水平，怀疑是污染物。该受试者和其他七个受试者的所有其他样品均未显示可检测的血浆DMPS。对照受试者具有可检测的尿液和血浆DMPS水平，并且尿液汞排泄增加。这些结果表明TD-DMPS未被吸收。 TD-DMPS后尿汞排泄没有增加。我们的结果认为TD-DMPS是无效的金属螯合剂。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
代理获取

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号