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首页> 美国卫生研究院文献>Scientific Reports >Epidural Dexmedetomidine Reduces the Requirement of Propofol during Total Intravenous Anaesthesia and Improves Analgesia after Surgery in Patients undergoing Open Thoracic Surgery
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Epidural Dexmedetomidine Reduces the Requirement of Propofol during Total Intravenous Anaesthesia and Improves Analgesia after Surgery in Patients undergoing Open Thoracic Surgery

机译：硬膜外右美托咪定可降低全胸腔麻醉患者全开麻醉期间对异丙酚的需求量并改善开胸手术患者术后的镇痛效果。

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The aim of this study was to assess the systemic and analgesic effects of epidural dexmedetomidine in thoracic epidural anaesthesia (TEA) combined with total intravenous anaesthesia during thoracic surgery. Seventy-one patients undergoing open thoracotomy were included in this study and randomly divided into three groups: Control group (Group C): patients received TEA with levobupivacaine alone and were intravenously infused with saline; Epidural group (Group E): patients received TEA with levobupivacaine and dexmedetomidine, and were intravenously infused with saline; Intravenous group (group V): patients received TEA with levobupivacaine alone and were intravenously infused with dexmedetomidine. The doses of propofol used in the induction and maintenance of general anaesthesia, cardiovascular response, dose and first time of postoperative analgesia and verbal rating scale were recorded. The induction and maintenance were significantly lower in the Groups E and V. Verbal rating scale and postoperative analgesic requirements were significantly lower in Group E than in Groups C and V. Patients in Group C had more severe cardiovascular responses, as compared with Groups E and V. Epidural administration of dexmedetomidine reduced the induction and maintenance of propofol, and inhibited the cardiovascular response after intubation and extubation. Moreover, epidural dexmedetomidine provided better analgesia after open thoracotomy.
机译：这项研究的目的是评估胸膜硬膜外麻醉（TEA）结合胸腔外科手术中的全身静脉麻醉对硬膜外右美托咪定的全身和镇痛作用。本研究纳入了71例行开胸手术的患者，并随机分为三组：对照组（C组）：仅接受左旋布比卡因治疗的TEA患者并静脉输注生理盐水。硬膜外治疗组（E组）：患者接受左旋布比卡因和右美托咪定治疗，静脉输注生理盐水。静脉组（V组）：患者接受仅含左旋布比卡因的TEA，并静脉注射右美托咪定。记录用于全身麻醉诱导和维持的丙泊酚剂量，心血管反应，术后镇痛的剂量和首次使用量以及口头评定量表。 E组和V组的诱导和维持显着降低。E组的口头评定量表和术后镇痛要求显着低于C组和V组。与E组和C组相比，C组患者的心血管反应更为严重。五，硬膜外给药右美托咪定减少了异丙酚的诱导和维持，并抑制了插管和拔管后的心血管反应。此外，硬膜外右美托咪定在开胸手术后提供了更好的镇痛作用。

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