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首页> 美国卫生研究院文献>Scientific Reports >Evaluation of intraretinal migration of retinal pigment epithelial cells in age-related macular degeneration using polarimetric imaging
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Evaluation of intraretinal migration of retinal pigment epithelial cells in age-related macular degeneration using polarimetric imaging

机译：偏光成像评估年龄相关性黄斑变性中视网膜色素上皮细胞的视网膜内迁移

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The purpose of the present study was to evaluate the intraretinal migration of the retinal pigment epithelium (RPE) cells in age-related macular degeneration (AMD) using polarimetry. We evaluated 155 eyes at various AMD stages. Depolarized light images were computed using a polarization-sensitive scanning laser ophthalmoscope (PS-SLO), and the degree of polarization uniformity was calculated using polarization-sensitive optical coherence tomography (OCT). Each polarimetry image was compared with the corresponding autofluorescence (AF) images at 488 nm (SW-AF) and at 787 nm (NIR-AF). Intraretinal RPE migration was defined by the presence of depolarization at intraretinal hyperreflective foci on PS-SLO and PS-OCT images, and by the presence of hyper-AF on both NIR-AF and SW-AF images. RPE migration was detected in 52 of 155 eyes (33.5%) and was observed in drusenoid pigment epithelial detachment (PED) and serous PED with significantly higher frequencies than in other groups (P = 0.015). The volume of the migrated RPE cluster in serous PED was significantly correlated with the volume of the PED (R2 = 0.26; P = 0.011). Overall, our results showed that intraretinal RPE migrations occurred in various AMD stages, and that they occurred more commonly in eyes with serous and drusenoid PED.
机译：本研究的目的是使用偏光法评估年龄相关性黄斑变性（AMD）中视网膜色素上皮（RPE）细胞的视网膜内迁移。我们评估了AMD不同阶段的155眼。使用偏振敏感扫描激光检眼镜（PS-SLO）计算去偏振图像，并使用偏振敏感光学相干断层扫描（OCT）计算偏振均匀度。将每个偏振计图像与相应的488 nm（SW-AF）和787 nm（NIR-AF）的自发荧光（AF）图像进行比较。视网膜内RPE迁移是由PS-SLO和PS-OCT图像上视网膜内高反射灶处的去极化作用以及NIR-AF和SW-AF图像上都存在超AF来定义的。在155只眼中有52只眼（33.5％）中检测到RPE迁移，并发现在肾小管类色素上皮脱离（PED）和浆液性PED中，其发生频率明显高于其他组（P = 0.015）。浆液性PED中RPE簇的迁移量与PED的量显着相关（R 2 = 0.26; P = 0.011）。总体而言，我们的结果表明，视网膜内RPE迁移发生在AMD的各个阶段，并且更常见于浆液性和类疣肾PED的眼睛。

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