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首页> 美国卫生研究院文献>AAPS PharmSciTech >Fabrication and In Vitro/In Vivo Performance of Mucoadhesive Electrospun Nanofiber Mats Containing α-Mangostin
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Fabrication and In Vitro/In Vivo Performance of Mucoadhesive Electrospun Nanofiber Mats Containing α-Mangostin

机译：含α-Mangostin的粘膜粘着性静电纺纳米纤维毡的制备及体外/体内性能

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This study aimed to fabricate mucoadhesive electrospun nanofiber mats containing α-mangostin for the maintenance of oral hygiene and reduction of the bacterial growth that causes dental caries. Synthesized thiolated chitosan (CS-SH) blended with polyvinyl alcohol (PVA) was selected as the mucoadhesive polymer. α-Mangostin was incorporated into the CS-SH/PVA solution and electrospun to obtain nanofiber mats. Scanning electron microscopy, differential scanning calorimetry, X-ray diffraction, and tensile strength testing were used to characterize the mats. The swelling degree and mucoadhesion were also determined. The nanofiber mats were further evaluated regarding their α-mangostin content, in vitro α-mangostin release, antibacterial activity, cytotoxicity, in vivo performance, and stability. The results indicated that the mats were in the nanometer range. The α-mangostin was well incorporated into the mats, with an amorphous form. The mats showed suitable tensile strength, swelling, and mucoadhesive properties. The loading capacity increased when the initial amount of α-mangostin was increased. Rapid release of α-mangostin from the mats was achieved. Additionally, a fast bacterial killing rate occurred at the lowest concentration of nanofiber mats when α-mangostin was added to the mats. The mats were less cytotoxic after use for 72 h. Moreover, in vivo testing indicated that the mats could reduce the number of oral bacteria, with a good mouth feel. The mats maintained the amount of α-mangostin for 6 months. The results suggest that α-mangostin-loaded mucoadhesive electrospun nanofiber mats may be a promising material for oral care and the prevention of dental caries.
机译：这项研究的目的是制造粘膜粘附的静电纺丝纳米纤维垫，其中包含α-芒果素，以维持口腔卫生并减少引起龋齿的细菌生长。选择与聚乙烯醇（PVA）共混的合成硫醇化壳聚糖（CS-SH）作为粘膜粘附聚合物。将α-Mangostin掺入CS-SH / PVA溶液中并进行电纺丝以获得纳米纤维毡。使用扫描电子显微镜，差示扫描量热法，X射线衍射和拉伸强度测试来表征垫。还测定了溶胀度和粘膜粘附性。进一步评估了纳米纤维垫的α-Mangostin含量，体外α-Mangostin释放，抗菌活性，细胞毒性，体内性能和稳定性。结果表明，垫在纳米范围内。 α-芒果被很好地掺入垫子中，呈无定形形式。垫子显示出合适的拉伸强度，膨胀性和粘膜粘附性。当α-芒果素的初始量增加时，负载能力增加。从席子中快速释放了α-芒果素。此外，当将α-Mangostin添加到纳米纤维垫中时，在最低浓度的纳米纤维垫上会出现快速的细菌杀灭率。使用72小时后，垫子的细胞毒性较小。此外，体内测试表明，垫子可以减少口腔细菌的数量，并具有良好的口感。席子维持6个月的α-芒果素含量。结果表明，负载α-芒果素的粘膜粘附静电纺丝纳米纤维垫可能是用于口腔护理和预防龋齿的有前途的材料。

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