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首页> 美国卫生研究院文献>Scientific Reports >A propensity-matched study of the association between optimal folic acid supplementation and birth defects in Shaanxi province Northwestern China
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A propensity-matched study of the association between optimal folic acid supplementation and birth defects in Shaanxi province Northwestern China

机译：西北地区陕西省最佳叶酸补充与出生缺陷之间关系的倾向匹配研究

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The association between folic acid supplementation and birth defects other than neural tube defects remains unclear. We utilized data from a large population-based survey to examine the association between folic acid supplementation and birth defects in Northwestern China. A total of 29,204 women with infants born between 2010 and 2013 were surveyed in Shaanxi province, Northwestern China, using a stratified multistage sampling method. Propensity scores were used to match 9,293 women with optimal folic acid supplementation with 9,293 women with nonoptimal folic acid supplementation, and the effects of optimal folic acid supplementation on birth defects were assessed by a conditional logistic regression model. After propensity score matching, the overall birth defect rate, cardiovascular system defect rate and nervous system defect rate for the women with optimal folic acid supplementation were lower than those for the women with nonoptimal folic acid supplementation (overall birth defects: OR = 0.71, 95% CI = 0.57–0.89, P = 0.003; cardiovascular system defects: OR = 0.65, 95% CI = 0.44–0.96, P = 0.032; nervous system defects: OR = 0.13, 95% CI = 0.02–0.99, P = 0.049). Optimal folic acid supplementation was associated with a decreased prevalence of birth defects, especially in the cardiovascular system and nervous system. Our findings have important implications for birth defect intervention with folic acid supplementation for countries with a high prevalence of birth defects, such as China.
机译：叶酸补充剂与除神经管缺陷以外的先天缺陷之间的关联尚不清楚。我们利用来自大型人口调查的数据来检验西北地区补充叶酸与出生缺陷之间的关系。我们采用分层多阶段抽样方法，对中国西北地区陕西省的29,204名妇女与2010年至2013年之间出生的婴儿进行了调查。倾向得分用于将9,293名最佳叶酸补充剂妇女与9,293名非最佳叶酸补充剂妇女进行匹配，并通过条件逻辑回归模型评估最佳叶酸补充剂对出生缺陷的影响。倾向得分匹配后，最佳叶酸补充剂妇女的总体出生缺陷率，心血管系统缺陷率和神经系统缺陷率低于非最佳叶酸补充剂的妇女（总体出生缺陷率：OR = 0.71，95 ％CI = 0.57–0.89，P = 0.003;心血管系统缺陷：OR = 0.65，95％CI = 0.44-0.96，P = 0.032;神经系统缺损：OR = 0.13，95％CI = 0.02-0.99，P = 0.049 ）。最佳叶酸补充剂可减少出生缺陷的患病率，尤其是在心血管系统和神经系统中。我们的发现对于出生缺陷患病率较高的国家（例如中国），对补充叶酸的出生缺陷干预具有重要意义。

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