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A Facile Approach to Fabricate Dual Purpose Hybrid Materials for Tissue Engineering and Water Remediation

机译:一种用于组织工程和水修复的双重用途混合材料的简便制造方法

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摘要

Creating hybrid materials with multifunctionality and robust mechanical stability from natural resources is a challenging proposition in materials science. Here, we report the scalable synthesis of hybrid collagen scaffolds using collagen extracted from leather industry wastes and sago starch derived from agro-industry. The hybrid scaffolds were incorporated with TiO2 nanoparticles and cross-linked with oxidized sago starch. The biocompatibility, thermal stability and antimicrobial property of hybrid scaffold enabled its application in burn wound healing demonstrated through albino rat models. The highly porous hybrid scaffolds are shown to be super-compressible, which is typically forbidden in materials of biological origin. We demonstrate that the hybrid scaffolds concurrently display both adsorption and absorption behavior in the removal of oil and dye molecules, respectively from contaminated water. This study paves the way for the development of novel multifunctional and shape recoverable hybrid materials specifically from renewable resources.
机译:利用自然资源创建具有多功能性和强大机械稳定性的混合材料在材料科学中是一个具有挑战性的主张。在这里,我们报告了使用从皮革工业废料中提取的胶原蛋白和从农业工业中提取的西米淀粉可扩展合成杂化胶原蛋白支架的方法。将杂化支架与TiO2纳米颗粒结合在一起,并与氧化西米淀粉交联。杂种支架的生物相容性,热稳定性和抗菌特性使其能够在白化病大鼠模型中证明其在烧伤创面愈合中的应用。高度多孔的杂种支架显示出是超可压缩的,这在生物来源的材料中通常是被禁止的。我们证明杂种支架同时在分别从受污染的水中去除油和染料分子时显示出吸附和吸收行为。这项研究为新型多功能和形状可恢复的混合材料的开发铺平了道路,这些材料特别是从可再生资源中开发的。

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