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首页> 美国卫生研究院文献>Scientific Reports >Levels of plasma neurofilament light chain and cognitive function in patients with Alzheimer or Parkinson disease
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Levels of plasma neurofilament light chain and cognitive function in patients with Alzheimer or Parkinson disease

机译：阿尔茨海默氏病或​​帕金森病患者血浆神经丝轻链水平和认知功能

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Plasma neurofilament light (NFL) has been proposed as a blood-based biomarker for neurodegeneration in Alzheimer’s disease (AD) and parkinsonian disorders. However, the relationship between plasma NFL and cognitive decline in dementia due to Parkinson’s disease (PD) remains to be elucidated. In this research, 119 AD, 56 mild cognitive impairment (MCI), 26 non-demented PD (PDND), and 23 Parkinson’s disease dementia (PDD) patients, as well as 59 cognitively healthy controls (HC) were recruited. Each subject underwent a battery of neuropsychological testing. Plasma NFL levels were measured in duplicate using an NF-Light assay and transferred onto the Simoa platform with a home-brew kit. Plasma NFL was significantly increased in the AD group, compared with the control, MCI, PDND, and PDD groups. Plasma NFL was significantly higher in the PDD group, compared with the PDND group. High plasma NFL correlated with poor cognition in AD and PD, but not with motor symptoms in PD. Plasma NFL may represent a biomarker of cognitive decline in AD and PD, with more specificity for AD.
机译：血浆神经丝灯（NFL）已被提议作为基于血液的生物标记物，用于阿尔茨海默氏病（AD）和帕金森氏病的神经退行性变。但是，血浆NFL与帕金森氏病（PD）引起的痴呆认知能力下降之间的关系尚待阐明。在这项研究中，招募了119位AD，56位轻度认知障碍（MCI），26位非痴呆PD（PDND）和23位帕金森氏病痴呆（PDD）患者以及59位认知健康对照（HC）。每个受试者都进行了一系列的神经心理学测试。使用NF-Light测定法一式两份测量血浆NFL水平，并使用自酿套件将其转移到Simoa平台上。与对照组，MCI，PDND和PDD组相比，AD组的血浆NFL显着增加。与PDND组相比，PDD组的血浆NFL显着更高。血浆NFL高与AD和PD的认知能力差有关，但与PD的运动症状无关。血浆NFL可能代表AD和PD认知能力下降的生物标志物，对AD更具特异性。

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