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首页> 美国卫生研究院文献>Scientific Reports >Metabolite accumulation and metabolic network in developing roots of Rehmannia glutinosa reveals its root developmental mechanism and quality
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Metabolite accumulation and metabolic network in developing roots of Rehmannia glutinosa reveals its root developmental mechanism and quality

机译：熟地黄根部代谢产物的积累和代谢网络揭示其根部发育机理和品质

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摘要

Rehmannia glutinosa root contains many compounds with important medicinal properties and nutritional benefits, but only more than 140 compounds have been reported so far. Many other compounds and their accumulation and metabolic networks during its development remain unclear. In order to clarify them, its metabolic profiles at three different developmental stages were analyzed using untargeted LC-MS analysis. Multivariate analysis revealed that 434 metabolites differently accumulated in its different stages, suggesting different change trends. The metabolites having the same trend share common metabolic pathways, the metabolites showing increasing contents during its development have medical and nutritional values, and some mature root-specific metabolites may be better candidates for its quality control; 434 metabolites were mapped onto 111 KEGG pathways including 62 enzymes, whose increasing and decreasing patterns were shown during its development. Some metabolites complicatedly interacted with some enzymes and the top-10 pathways enriched from 111 KEGG pathways in network analysis. These findings extended the dataset of its identified compounds, and revealed that its development and quality were associated with the accumulation of different metabolites. Our work will lay the foundation for the better understanding of its chemical constituents, quality and developmental mechanism.
机译：熟地黄的根中含有许多具有重要医学特性和营养价值的化合物，但迄今为止，仅报道了140多种化合物。尚不清楚许多其他化合物及其在发展过程中的积累和代谢网络。为了澄清它们，使用非靶向LC-MS分析法分析了其在三个不同发育阶段的代谢谱。多变量分析表明，434种代谢物在其不同阶段的积累不同，表明变化趋势不同。具有相同趋势的代谢物具有共同的代谢途径，在其发育过程中含量增加的代谢物具有医学和营养价值，某些成熟的根系特异性代谢物可能是对其质量控制的更好候选者。 434种代谢物被定位到111种KEGG途径上，包括62种酶，在其发育过程中表现出增加和减少的模式。在网络分析中，一些代谢物与某些酶复杂地相互作用，并且从111个KEGG途径中富集了前10个途径。这些发现扩展了其鉴定化合物的数据集，并揭示了其发展和质量与不同代谢产物的积累有关。我们的工作将为更好地了解其化学成分，质量和发展机理奠定基础。

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