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首页> 美国卫生研究院文献>Scientific Reports >Readout-segmented echo-planar diffusion-weighted MR for the evaluation of aggressive characteristics of rectal cancer
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Readout-segmented echo-planar diffusion-weighted MR for the evaluation of aggressive characteristics of rectal cancer

机译：读数分段回波平面扩散加权MR评估直肠癌的侵袭性

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To evaluate whether aggressive characteristics of rectal cancer can be predicted by the apparent diffusion coefficient (ADC) obtained using readout-segmented echo-planar imaging (rs-EPI) diffusion-weighted magnetic resonance. We enrolled one hundred and fifteen patients. The image quality of ADC maps by rs-EPI was compared with that by traditional single-shot echo-planar imaging (ss-EPI), and ADC measurement was performed on the rs-EPI based ADC maps. Differences in ADC values of tumors grouped according to differentiation grade, clinical T stage and plasmatic carcinoembryonic antigen (CEA) level were tested. The correlation between each aggressive characteristic and the corresponding ADC values was evaluated. The image quality of ADC maps obtained by rs-EPI was superior toss-EPI (P < 0.05). The ADC values of tumor were categorized based on the following differentiation grades: poor (0.89 ± 0.12 × 10−3 mm2/s), moderate (1.13 ± 0.25 × 10−3 mm2/s), and good (1.31 ± 0.19 × 10−3 mm2/s); P < 0.001. Tumors with lower differentiation grades corresponded to lower ADC values (r = 0.59, P < 0.001). However, ADC differences were not observed in different clinical T stage (P = 0.22) and plasmatic CEA level (P = 0.38). Rs-EPI sequence-based ADC values represent a potential imaging marker for the aggressive rectal cancer characteristics.
机译：为了评估是否可以通过使用读出分段回波平面成像（rs-EPI）扩散加权磁共振获得的表观扩散系数（ADC）预测直肠癌的侵袭性特征。我们招募了115名患者。将rs-EPI与传统单次回波平面成像（ss-EPI）的ADC图的图像质量进行比较，并对基于rs-EPI的ADC图执行ADC测量。测试了根据分化程度，临床T期和血浆癌胚抗原（CEA）水平分组的肿瘤ADC值的差异。评估了每个攻击性特征与相应ADC值之间的相关性。 rs-EPI获得的ADC图的图像质量优于sss-EPI（P <0.05）。肿瘤的ADC值根据以下区分等级进行分类：差（0.89±0.12×10 −3 mm 2 / s），中度（1.13±0.25×10 −3 mm 2 / s）和良好（1.31±0.19×10 −3 mm 2 / s ）; P ＜0.001。分化程度较低的肿瘤对应较低的ADC值（r = 0.59，P <0.001）。然而，在不同的临床T期（P = 0.22）和血浆CEA水平（P = 0.38）未观察到ADC差异。基于Rs-EPI序列的ADC值代表了积极的直肠癌特征的潜在成像标志。

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