• 主题
高级搜索  >
历史搜索 清空历史
首页> 美国卫生研究院文献>Scientific Reports >The effect of succinate on brain NADH/NAD+ redox state and high energy phosphate metabolism in acute traumatic brain injury
【2h】

The effect of succinate on brain NADH/NAD+ redox state and high energy phosphate metabolism in acute traumatic brain injury

机译：琥珀酸酯对急性脑外伤后脑NADH / NAD +氧化还原状态和高能磷酸盐代谢的影响

代理获取
本网站仅为用户提供外文OA文献查询和代理获取服务，本网站没有原文。下单后我们将采用程序或人工为您竭诚获取高质量的原文，但由于OA文献来源多样且变更频繁，仍可能出现获取不到、文献不完整或与标题不符等情况，如果获取不到我们将提供退款服务。请知悉。
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

A key pathophysiological process and therapeutic target in the critical early post-injury period of traumatic brain injury (TBI) is cell mitochondrial dysfunction; characterised by elevation of brain lactate/pyruvate (L/P) ratio in the absence of hypoxia. We previously showed that succinate can improve brain extracellular chemistry in acute TBI, but it was not clear if this translates to a change in downstream energy metabolism. We studied the effect of microdialysis-delivered succinate on brain energy state (phosphocreatine/ATP ratio (PCr/ATP)) with 31P MRS at 3T, and tissue NADH/NAD+ redox state using microdialysis (L/P ratio) in eight patients with acute major TBI (mean 7 days). Succinate perfusion was associated with increased extracellular pyruvate (+26%, p < 0.0001) and decreased L/P ratio (−13%, p < 0.0001) in patients overall (baseline-vs-supplementation over time), but no clear-cut change in 31P MRS PCr/ATP existed in our cohort (p > 0.4, supplemented-voxel-vs-contralateral voxel). However, the percentage decrease in L/P ratio for each patient following succinate perfusion correlated significantly with their percentage increase in PCr/ATP ratio (Spearman's rank correlation, r = −0.86, p = 0.024). Our findings support the interpretation that L/P ratio is linked to brain energy state, and that succinate may support brain energy metabolism in select TBI patients suffering from mitochondrial dysfunction.
机译：在创伤性脑损伤（TBI）的关键伤后早期，关键的病理生理过程和治疗目标是细胞线粒体功能障碍。缺氧时脑乳酸/丙酮酸（L / P）比升高。我们以前曾证明琥珀酸可以改善急性TBI中的脑细胞外化学，但尚不清楚这是否转化为下游能量代谢的改变。我们研究了微透析递送的琥珀酸酯对3t时 31 P MRS和组织NADH / NAD + 使用微透析（L / P比）的氧化还原状态在8例急性大TBI患者中（平均7天）。总体上，琥珀酸灌注与细胞外丙酮酸增加（+ 26％，p <0.0001）和L / P比降低（−13％，p <0.0001）相关（随着时间的推移基线-vs-补充），但没有明确的关联我们的队列中存在 31 P MRS PCr / ATP的变化（p> 0.4，补充体素-对侧对体素）。然而，每例患者在琥珀酸盐灌注后的L / P百分比降低与他们的PCr / ATP比例百分比显着相关（Spearman等级相关，r = -0.86，p = 0.024）。我们的发现支持以下解释：L / P比与脑能量状态有关，而琥珀酸可能支持线粒体功能障碍的部分TBI患者的脑能量代谢。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
代理获取

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号