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首页> 美国卫生研究院文献>Scientific Reports >Proteomics Studies on the three Larval Stages of Development and Metamorphosis of Babylonia areolata
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Proteomics Studies on the three Larval Stages of Development and Metamorphosis of Babylonia areolata

机译：乳白巴比伦发育和变态的三个幼虫阶段的蛋白质组学研究

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摘要

The ivory shell, Babylonia areolata, is a commercially important aquaculture species in the southeast coast of mainland China. The middle veliger stage, later veliger stage, and juvenile stage are distinct larval stages in B. areolata development. In this study, we used label-free quantification proteomics analysis of the three developmental stages of B. areolata. We identified a total of 5,583 proteins, of which 1,419 proteins expression level showed significant differential expression. The results of gene ontology enrichment analysis showed that the number of proteins involved in metabolic and cellular processes were the most abundant. Those proteins mostly had functions such as binding, catalytic activity and transporter activity. The results of Kyoto Encyclopedia of Genes and Genomes enrichment analysis showed that the number of proteins involved in the ribosome, carbon metabolism, and lysosome pathways were the most abundant, indicating that protein synthesis and the immune response were active during the three stages of development. This is the first study to use proteomics and real-time PCR to study the early developmental stages of B. areolata, which could provide relevant data on gastropod development. Our results provide insights into the novel aspects of protein function in shell formation, body torsion, changes in feeding habits, attachment and metamorphosis, immune-related activities in B. areolata larvae.
机译：象牙壳巴比伦乳晕是中国大陆东南沿海的一种重要的水产养殖物种。中间油菜阶段，后期油菜阶段和少年阶段是乳白芽孢杆菌发育的不同幼体阶段。在这项研究中，我们使用了乳白芽孢杆菌三个发育阶段的无标记定量蛋白质组学分析。我们鉴定出总共5,583个蛋白质，其中1,419个蛋白质表达水平显示出明显的差异表达。基因本体富集分析的结果表明，参与代谢和细胞过程的蛋白质数量最多。这些蛋白质大部分具有诸如结合，催化活性和转运蛋白活性的功能。京都基因与基因组百科全书的富集分析结果表明，参与核糖体，碳代谢和溶酶体途径的蛋白质数量最多，表明蛋白质的合成和免疫反应在发育的三个阶段均活跃。这是首次使用蛋白质组学和实时PCR研究乳臭双歧杆菌的早期发育阶段的研究，该研究可提供有关腹足动物发育的相关数据。我们的结果提供了洞察B. areolata幼虫的蛋白质在壳形成，身体扭曲，进食习惯变化，附着和变态以及免疫相关活动方面的新颖方面的见识。

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