• 主题
高级搜索  >
历史搜索 清空历史
首页> 美国卫生研究院文献>Scientific Reports >Noise-induced bistability in the fate of cancer phenotypic quasispecies: a bit-strings approach
【2h】

Noise-induced bistability in the fate of cancer phenotypic quasispecies: a bit-strings approach

机译：癌症表型准种的命运中的噪声诱导的双稳态：位串方法

代理获取
本网站仅为用户提供外文OA文献查询和代理获取服务，本网站没有原文。下单后我们将采用程序或人工为您竭诚获取高质量的原文，但由于OA文献来源多样且变更频繁，仍可能出现获取不到、文献不完整或与标题不符等情况，如果获取不到我们将提供退款服务。请知悉。
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Tumor cell populations are highly heterogeneous. Such heterogeneity, both at genotypic and phenotypic levels, is a key feature during tumorigenesis. How to investigate the impact of this heterogeneity in the dynamics of tumors cells becomes an important issue. Here we explore a stochastic model describing the competition dynamics between a pool of heterogeneous cancer cells with distinct phenotypes and healthy cells. This model is used to explore the role of demographic fluctuations on the transitions involving tumor clearance. Our results show that for large population sizes, when demographic fluctuations are negligible, there exists a sharp transition responsible for tumor cells extinction at increasing tumor cells’ mutation rates. This result is consistent with a mean field model developed for the same system. The mean field model reveals only monostability scenarios, in which either the dominance of the tumor cells or the dominance of the healthy cells is found. Interestingly, the stochastic model shows that for small population sizes the monostability behavior disappears, involving the presence of noise-induced bistability. The impact of the initial populations of cells in the fate of the cell populations is investigated, as well as the transient times towards the healthy and the cancer states.
机译：肿瘤细胞群体高度异质。在基因型和表型水平上的这种异质性是肿瘤发生期间的关键特征。如何研究这种异质性对肿瘤细胞动力学的影响成为一个重要的问题。在这里，我们探索了一个随机模型，该模型描述了具有不同表型的异种癌细胞池与健康细胞之间的竞争动态。该模型用于探讨人口统计波动在涉及肿瘤清除的转变中的作用。我们的研究结果表明，对于人口众多的人群，当人口统计波动可忽略不计时，存在急剧的过渡，导致肿瘤细胞以更高的肿瘤细胞突变率灭绝。该结果与为相同系统开发的平均场模型一致。平均场模型仅揭示了单稳态情况，在该情况下，发现了肿瘤细胞的优势或健康细胞的优势。有趣的是，随机模型表明，对于较小的人口规模，单稳态行为会消失，其中包括噪声引起的双稳态。研究了初始细胞种群对细胞种群命运的影响，以及向健康和癌症状态过渡的时间。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
代理获取

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号