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首页> 美国卫生研究院文献>Scientific Reports >Exosomal microRNAs in giant panda (Ailuropoda melanoleuca) breast milk: potential maternal regulators for the development of newborn cubs
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Exosomal microRNAs in giant panda (Ailuropoda melanoleuca) breast milk: potential maternal regulators for the development of newborn cubs

机译：大熊猫（Ailuropoda melanoleuca）母乳中的外泌体microRNA：潜在的母体调节因子用于新生幼崽的发育

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The physiological role of miRNAs is widely understood to include fine-tuning the post-transcriptional regulation of a wide array of biological processes. Extensive studies have indicated that exosomal miRNAs in the bodily fluids of various organisms can be transferred between living cells for the delivery of gene silencing signals. Here, we illustrated the expression characteristics of exosomal miRNAs in giant panda breast milk during distinct lactation periods and highlighted the enrichment of immune- and development-related endogenous miRNAs in colostral and mature giant panda milk. These miRNAs are stable, even under certain harsh conditions, via the protection of extracellular vesicles. These findings indicate that breast milk may facilitate the dietary intake of maternal miRNAs by infants for the regulation of postnatal development. We also detected exogenous plant miRNAs from the primary food source of the giant panda (bamboo) in the exosomes of giant panda breast milk that were associated with regulatory roles in basic metabolism and neuron development. This result suggested that dietary plant miRNAs are absorbed by host cells and subsequently secreted into bodily fluids as potential cross-kingdom regulators. In conclusion, exosomal miRNAs in giant panda breast milk may be crucial maternal regulators for the development of intrinsic ‘slink’ newborn cubs.
机译：miRNA的生理作用被广泛理解为包括微调多种生物过程的转录后调控。广泛的研究表明，各种生物体液中的外泌体miRNA可以在活细胞之间转移，从而传递基因沉默信号。在这里，我们阐明了外泌性miRNA在不同哺乳期在大熊猫母乳中的表达特征，并强调了初乳和成熟大熊猫乳中与免疫和发育相关的内源性miRNA的富集。通过保护细胞外囊泡，即使在某些恶劣条件下，这些miRNA也是稳定的。这些发现表明，母乳可能有助于婴儿从饮食中摄取母体miRNA，以调节产后发育。我们还从大熊猫母乳的外泌体中检测到了来自大熊猫（竹子）主要食物来源的外源植物miRNA，它们与基础代谢和神经元发育中的调节作用有关。该结果表明，饮食植物miRNA被宿主细胞吸收，并随后作为潜在的跨王国调控因子被分泌到体液中。总之，大熊猫母乳中的外泌体miRNA可能是内在的“潜伏”新生幼崽发育的重要母体调节因子。

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