High doses of minocycline may induce delayed activation of microglia in aged rats and thus cannot prevent postoperative cognitive dysfunction

机译：高剂量的美满霉素可能会导致衰老大鼠小胶质细胞的激活延迟因此无法预防术后认知功能障碍

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ObjectivePostoperative cognitive dysfunction (POCD) is common after surgery in elderly patients and is associated with high morbidity. The molecular mechanisms responsible for POCD are unknown. Minocycline, an inhibitor of microglial activation, may be useful in treating and preventing POCD. We explored whether minocycline can inhibit microglial activation and prevent POCD in aged rats as a surgery model.

机译：目的老年患者术后常见认知功能障碍（POCD），并与高发病率相关。造成POCD的分子机制尚不清楚。米诺环素是小胶质细胞活化的抑制剂，可用于治疗和预防POCD。我们探讨了米诺环素是否可以抑制老年大鼠的小胶质细胞活化并预防POCD。

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期刊名称 The Journal of International Medical Research
作者
Wenyao Li; Qing Chai; Hongwei Zhang; Jing Ma; Chengfen Xu; Jifu Dong; Xianghua Wei; Zhiyi Wang; Kexian Zhang;
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作者单位

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年(卷),期 2018(46),4
年度 2018
页码 1404–1413
总页数 10
原文格式 PDF
正文语种
中图分类药学;医学史;
关键词
Minocycline inflammation microglia aged rat postoperative cognitive dysfunction surgery model;

机译：米诺环素;炎症;小胶质细胞;老年大鼠;术后认知功能障碍;手术模型;

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专利

1. High doses of minocycline may induce delayed activation of microglia in aged rats and thus cannot prevent postoperative cognitive dysfunction [J] . Wenyao Li, Qing Chai, Hongwei Zhang, Journal of International Medical Research . 2018,第4期

机译：高剂量的美满霉素可能会导致衰老大鼠小胶质细胞的激活延迟，因此无法预防术后认知功能障碍
2. Electroacupuncture Alleviates Postoperative Cognitive Dysfunction in Aged Rats by Inhibiting Hippocampal Neuroinflammation Activated via Microglia/TLRs Pathway [J] . Feng Pei-pei, Deng Pu, Liu Li-hua, Evidence-based complementary and alternative medicine: eCAM . 2017,第6期

机译：通过抑制通过微胶质细胞/ TLRS途径激活的海马神经炎炎症来缓解老鼠术后认知功能障碍的术后认知功能障碍
3. Nicotine-induced neuroprotection against postoperative cognitive dysfunction involves activation of the BDNF/TrkB signalling pathway and inhibition of the NF-kappa B signalling pathway in aged rats [J] . Wei P., Zheng Q., Zhou J., British journal of anaesthesia . 2017,第4期

机译：尼古丁诱导的针对术后认知功能障碍的神经保护障碍涉及激活BDNF / TRKB信号通路和抑制老年大鼠的NF-Kappa B信号通路
4. The effect of the application of desflurane combined with dexmedetomidine to postoperative cognitive dysfunction in the aged rats [C] . Shanshan Yu, Dongmei Li, Jinlan Wang International Conference on Biological Information and Biomedical Engineering . 2019

机译：DEXFORANE与DEXMEDETOMIDINAD施用效果对老年大鼠术后认知功能障碍的影响
5. In Postoperative Patients Ages 1 to 12 What Is the Maximum Rapid Bolus Dose of Precedex (Dexmedetomidine) that Will Not Cause a Clinically Significant Alteration in Hemodynamics? [D] . Martin, Samuel T. 2020

机译：在术后1至12岁的患者中，什么是最大的快速推注剂量的前一种（Dexmedetomidine），不会导致血流动力学的临床显着改变？
6. Electroacupuncture Alleviates Postoperative Cognitive Dysfunction in Aged Rats by Inhibiting Hippocampal Neuroinflammation Activated via Microglia/TLRs Pathway [O] . Pei-pei Feng, Pu Deng, Li-hua Liu, 2017

机译：电针通过抑制小胶质细胞/ TLRs途径激活的海马神经炎症减轻老年大鼠的术后认知功能障碍
7. High doses of minocycline may induce delayed activation of microglia in aged rats and thus cannot prevent postoperative cognitive dysfunction [O] . Wenyao Li, Qing Chai, Hongwei Zhang, 2018

机译：高剂量的米诺环素可以诱导老年大鼠中小胶质细胞的延迟激活，因此不能防止术后认知功能障碍

High doses of minocycline may induce delayed activation of microglia in aged rats and thus cannot prevent postoperative cognitive dysfunction

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