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首页> 美国卫生研究院文献>Scientific Reports >Yu Ping Feng San reverses cisplatin-induced multi-drug resistance in lung cancer cells via regulating drug transporters and p62/TRAF6 signalling
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Yu Ping Feng San reverses cisplatin-induced multi-drug resistance in lung cancer cells via regulating drug transporters and p62/TRAF6 signalling

机译：于平风散通过调节药物转运蛋白和p62 / TRAF6信号转导逆转顺铂诱导的肺癌多药耐药

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摘要

Yu Ping Feng San (YPFS), an ancient Chinese herbal decoction composed of Astragali Radix, Atractylodis Macrocephalae Rhizoma and Saposhnikoviae Radix, has been used in the clinic for treating immune deficiency. In cancer therapy, YPFS is being combined with chemotherapy drugs to achieve improved efficacy; however, scientific evidence to illustrate this combination effect is lacking. The present study aims to demonstrate the anti-drug resistance of YPFS in cisplatin (DDP)-resistant non-small cell lung cancer cells (A549/DDP). The application of YPFS exhibited a synergistic enhancement of DDP-induced cytotoxicity as well as of the apoptotic signalling molecules. DDP-induced expression of the multi-drug-resistance efflux transporters was markedly reduced in the presence of YPFS, resulting in a higher intracellular concentration of DDP. In addition, the application of YPFS increased DDP-induced ROS accumulation and MMP depletion, decreased p62/TRAF6 signalling in DDP-treated A549/DDP cells. The co-treatment of DDP and YPFS in tumour-bearing mice reduced the tumour size robustly (by more than 80%), which was much better than the effect of DDP alone. These results indicate that YPFS can notably improve the DDP-suppressed cancer effect, which may be a consequence of the elevation of intracellular DDP via the drug transporters as well as the down regulation of p62/TRAF6 signalling.
机译：玉屏风散（YPFS）是一种由黄芪，白术和山茱S组成的古老中草药汤，已在临床上用于治疗免疫缺陷。在癌症治疗中，YPFS与化学疗法药物联合使用可提高疗效。但是，缺乏科学的证据来说明这种组合效应。本研究旨在证明YPFS在顺铂（DDP）耐药的非小细胞肺癌细胞（A549 / DDP）中具有抗药性。 YPFS的应用显示出DDP诱导的细胞毒性以及凋亡信号分子的协同增强。在存在YPFS的情况下，DDP诱导的多药耐药性外排转运蛋白的表达显着降低，导致细胞内DDP浓度更高。此外，YPFS的应用增加了DDP处理的A549 / DDP细胞中DDP诱导的ROS积累和MMP消耗，降低了p62 / TRAF6信号传导。在荷瘤小鼠中DDP和YPFS的共同治疗可有效地减小肿瘤大小（减少80％以上），这比单独使用DDP的效果要好得多。这些结果表明，YPFS可以显着改善DDP抑制的癌症作用，这可能是通过药物转运蛋白升高细胞内DDP以及下调p62 / TRAF6信号传导的结果。

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