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首页> 美国卫生研究院文献>Scientific Reports >Plasminogen Activator Inhibitor-1 in depression: Results from Animal and Clinical Studies
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Plasminogen Activator Inhibitor-1 in depression: Results from Animal and Clinical Studies

机译：抑郁症中的纤溶酶原激活物抑制剂1：来自动物和临床研究的结果

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摘要

Evidence suggests that plasminogen activator inhibitor-1 (PAI-1) is a stress-related factor, and serum PAI-1 levels are increased in patients with major depressive disorders (MDD). Herein, we analysed PAI-1 protein levels in the brain, cerebrospinal fluid (CSF) and serum of rodents exposed to chronic unpredictable mild stress or treated with escitalopram. In addition, we examined PAI-1 concentrations in serum obtained from 17 drug-free depressed patients before and after escitalopram treatment. We found that PAI-1 expression was increased in area 1 of the cingulate cortex and prelimbic cortex of the medial prefrontal cortex as well as in the hippocampal cornu ammonis 3 and dentate gyrus in stressed rats. A downregulation of PAI-1 following chronic escitalopram treatment was also found. PAI-1 levels were higher in the CSF and serum in stressed rats than in controls, although the difference did not reach statistical significance in the serum. Escitalopram treatment significantly decreased PAI-1 levels in the serum, but not in the CSF. MDD patients had significantly greater serum PAI-1 concentrations than controls. Our results suggest that PAI-1 is implicated in the pathophysiology of depression.
机译：有证据表明，纤溶酶原激活物抑制剂1（PAI-1）是与压力有关的因子，患有严重抑郁症（MDD）的患者血清PAI-1水平升高。在这里，我们分析了暴露于慢性不可预测的轻度压力或用依他普仑治疗的啮齿动物的大脑，脑脊液（CSF）和血清中PAI-1蛋白的水平。此外，我们检查了依他普仑治疗前后从17名无毒品抑郁患者中获得的血清中PAI-1的浓度。我们发现，在应激大鼠中，内侧前额叶皮层的扣带状皮层和前缘皮层1区以及海马角膜氨3和齿状回中的PAI-1表达增加。还发现慢性依西酞普兰治疗后PAI-1的下调。应激大鼠的CSF和血清中PAI-1水平高于对照组，尽管差异在血清中未达到统计学意义。依西酞普兰治疗可显着降低血清中PAI-1水平，但不能降低CSF中的PAI-1水平。 MDD患者的血清PAI-1浓度明显高于对照组。我们的结果表明，PAI-1与抑郁症的病理生理有关。

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