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首页> 美国卫生研究院文献>Scientific Reports >Determination of oxygen extraction fraction using magnetic resonance imaging in canine models with internal carotid artery occlusion
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Determination of oxygen extraction fraction using magnetic resonance imaging in canine models with internal carotid artery occlusion

机译：磁共振成像法在颈内动脉闭塞的犬模型中测定氧提取分数

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摘要

Perfusion of the penumbra tissue below the flow threshold for functional disturbance but above that for the maintenance of morphological integrity is the target for therapy in acute ischaemic stroke. The measurement of the oxygen extraction fraction (OEF) may provide a direct assessment of tissue viability, so that irreversible tissue damage and penumbra can be reliably identified. By using an asymmetric spin echo single-shot echo planar imaging (ASE-SSEPI) sequence, the quantitative OEF was obtained in the ischaemic brain tissues of canine models with internal carotid artery occlusion. TTC staining, which delineated the regions of infarct and penumbra, was used for defining the corresponding regions on OEF maps. The threshold of the OEF to discriminate the infarct cores and penumbral tissues was then determined according to the OEF values at different times. With repeated-measures ANOVA, the OEF of the infarcted regions was found to be time dependent. An OEF greater than 0.48 best predicted cortical infarction at 1.5 hr, with an area under the receiving operating characteristic curve of 0.968, a sensitivity of 97.5%, and a specificity of 92.5%. Our results may be helpful in the evaluation of tissue viability during stroke events.
机译：半影组织的灌注低于功能障碍的血流阈值，但高于维持形态完整性的阈值是急性缺血性卒中治疗的目标。氧气提取分数（OEF）的测量可以直接评估组织的生存能力，因此可以可靠地识别出不可逆的组织损伤和半影。通过使用非对称自旋回波单次回波平面成像（ASE-SSEPI）序列，在颈内动脉闭塞的犬模型的缺血性脑组织中获得了定量的OEF。描绘梗塞和半影区域的TTC染色用于定义OEF图上的相应区域。然后根据在不同时间的OEF值确定区分梗塞核心和半影组织的OEF阈值。使用重复测量方差分析，发现梗塞区域的OEF与时间有关。 OEF值大于0.48最好地预测1.5？hr时的皮质梗塞，其接收操作特征曲线下的面积为0.968，灵敏度为97.5％，特异性为92.5％。我们的结果可能有助于评估中风事件期间的组织活力。

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